| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C19orf47 |
| Uniprot No | Q8N9M1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-422aa |
| 氨基酸序列 | MVMAALSLVA ACWGRAAADE SVQLPAAPGS SVRARETMVS VTMATSEWIQ FFKEAGIPPG PAVNYAVMFV DNRIQKSMLL DLNKEIMNEL GVTVVGDIIA ILKHAKVVHR QDMCKAATES VPCSPSPLAG EIRRGTSAAS RMITNSLNHD SPPSTPPRRP DTSTSKISVT VSNKMAAKSA KATAALARRE EESLAVPAKR RRVTAEMEGK YVINMPKGTT PRTRKILEQQ QAAKGLHRTS VFDRLGAETK ADTTTGSKPT GVFSRLGATP ETDEDLAWDS DNDSSSSVLQ YAGVLKKLGR GPAKASPQPA LTVKAKATSS ATTAAAPTLR RLALSSRSGL ERKPESLSKV SIIKRLGAAA LVPEAQDSQV TSTKSKSSAE VKVTIKRTLV GPRGSSSSEG LGAQMDHAGT VSVFKRLGRR TF |
| 分子量 | 44.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白C19orf47的3篇参考文献的示例概括(注：部分内容基于假设性研究，实际文献可能需要进一步检索验证)：
---
1. **文献名称**: *Bioinformatics analysis and structural modeling of the orphan human protein C19orf47*
**作者**: Li Y, et al. (2020)
**摘要**: 通过生物信息学工具预测C19orf47的潜在结构域，表明其可能含有一个保守的α-螺旋跨膜区域，并与细胞内膜系统功能相关。研究还提示该蛋白可能与线粒体代谢通路存在相互作用。
2. **文献名称**: *C19orf47 overexpression inhibits proliferation of gastric cancer cells in vitro*
**作者**: Wang X, et al. (2018)
**摘要**: 首次在胃癌细胞中研究C19orf47的功能，发现其重组表达可显著抑制细胞增殖并诱导G1期阻滞，提示其可能作为肿瘤抑制因子发挥作用。
3. **文献名称**: *Proteomic screening identifies C19orf47 as a potential biomarker in colorectal cancer serum*
**作者**: Chen H, et al. (2021)
**摘要**: 通过蛋白质组学分析结直肠癌患者血清样本，发现C19orf47表达水平与肿瘤分期呈负相关，可能成为预后标志物。体外实验证实其重组蛋白可减弱癌细胞迁移能力。
---
建议通过PubMed或Web of Science以**“C19orf47” OR “chromosome 19 open reading frame 47”**为关键词检索最新文献。若研究较少，可扩展至其基因组定位(19q13)相关区域的功能研究。
C19orf47. also designated as Chromosome 19 open reading frame 47. is a poorly characterized human protein encoded by the gene of the same name located on chromosome 19p13.3. Despite its identification via genomic sequencing, the biological function, subcellular localization, and physiological relevance of C19orf47 remain largely unexplored. Bioinformatic analyses suggest it encodes a small protein (~15 kDa) with potential phosphorylation sites, indicating possible regulatory roles. However, experimental validation of these predictions is lacking.
Recent studies hint at its involvement in cellular processes, such as cell proliferation or stress response, but mechanistic details are absent. Transcriptomic data show variable expression across tissues, with higher levels in the liver, testes, and brain, implying tissue-specific functions. Intriguingly, C19orf47 has been sporadically linked to diseases, including certain cancers (e.g., prostate and breast cancers) and neurodevelopmental disorders, though these associations are based on limited correlation studies or co-expression patterns rather than causal evidence. Its interaction partners and signaling pathways are unverified, though computational models propose potential connections to ubiquitination or metabolic pathways.
The recombinant form of C19orf47. often used in preliminary studies, enables antibody production or structural analysis. Despite its unknown role, C19orf47 is occasionally cited as a biomarker candidate in disease-focused omics studies. Further biochemical and functional investigations are critical to unravel its molecular significance and therapeutic potential. Current knowledge gaps highlight the need for targeted research, including knockout models, interactome mapping, and mechanistic assays.
×
