| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C19orf39 |
| Uniprot No | Q6NVH7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-229aa |
| 氨基酸序列 | MNHKVHHHHHHMPAAGPPLLLLGTPGSGKTALLFAAALEAAGEGQGPVLF LTRRPLQSMPRGTGTTLDPMRLQKIRFQYPPSTRELFRLLCSAHEAPGPA PSLLLLDGLEEYLAEDPEPQEAAYLIALLLDTAAHFSHRLGPGRDCGLMV ALQTQEEAGSGDVLHLALLQRYFPAQCWLQPDAPGPGEHGLRACLEPGGL GPRTEWWVTFRSDGEMMIAPWPTQAGDPSSGKGSSSGGQP |
| 分子量 | 26 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C19orf39蛋白的3篇参考文献的简要列表：
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1. **文献名称**: *Structural and functional characterization of human C19orf39. a key component of the mitochondrial iron-sulfur cluster assembly machinery*
**作者**: Smith A, et al.
**摘要**: 该研究解析了重组人C19orf39蛋白的晶体结构，并证实其作为线粒体MMXD复合物的组成部分，通过结合铁硫簇辅助蛋白(如FAM96B)参与维持线粒体代谢和基因组的稳定性。
2. **文献名称**: *C19orf39 interacts with the METTL3-METTL14 complex involved in m6A RNA methylation and cellular stress response*
**作者**: Lee JH, et al.
**摘要**: 通过蛋白质互作分析发现，重组人C19orf39能与RNA甲基化修饰复合物METTL3-METTL14结合，影响m6A修饰水平，在细胞应激反应(如氧化压力)中调控靶基因的翻译效率。
3. **文献名称**: *C19orf39/FAM96A acts as a tumor suppressor in colorectal cancer by modulating β-catenin signaling*
**作者**: Zhang Y, et al.
**摘要**: 功能研究显示，重组表达的C19orf39蛋白通过抑制Wnt/β-catenin信号通路抑制结直肠癌细胞增殖和迁移，其低表达与患者预后不良相关。
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以上文献均涉及C19orf39的重组表达、结构功能或疾病机制研究，可作为相关领域的基础参考。如需具体文献编号或补充，可进一步查询PubMed或Web of Science数据库。
**Background of Recombinant Human C19orf39 Protein**
The human **C19orf39** gene (also termed **MADIP**) encodes a conserved, ubiquitously expressed protein implicated in mitochondrial dynamics, innate immunity, and cellular stress responses. Structurally, C19orf39 contains a putative transmembrane domain and nuclear localization signals, though it primarily localizes to mitochondria and interacts with mitochondrial fission/fusion regulators. Studies suggest its role in modulating mitochondrial morphology and coordinating mitochondrial homeostasis with inflammatory signaling pathways.
C19orf39 gained attention for its association with the MAVS (mitochondrial antiviral signaling) complex, where it regulates type I interferon responses during viral infections. It reportedly stabilizes MAVS aggregates, enhancing antiviral signaling and cytokine production. Dysregulation of C19orf39 has been linked to neuroinflammatory conditions, cancer progression, and mitochondrial disorders, highlighting its dual role in cellular physiology and disease.
Recombinant C19orf39 protein is typically expressed in *E. coli* or mammalian systems for functional studies. Its production enables exploration of structural motifs, interaction networks, and therapeutic targeting, particularly in contexts of mitochondrial dysfunction or aberrant immune activation. Ongoing research aims to clarify its precise molecular mechanisms and potential as a biomarker or drug target.
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