| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C19orf37 |
| Uniprot No | Q96B54 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-188aa |
| 氨基酸序列 | MTETREPAET GGYASLEEDD EDLSPGPEHS SDSEYTLSEP DSEEEEDEEE EEEETTDDPE YDPGYKVKQR LGGGRGGPSR RAPRAAQPPA QPCQLCGRSP LGEAPPGTPP CRLCCPATAP QEAPAPEGRA LGEEEEEPPR AGEGRPAGRE EEEEEEEEGT YHCTECEDSF DNLGELHGHF MLHARGEV |
| 分子量 | 46.9 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与重组人C19orf37蛋白相关的文献摘要示例(注：部分文献信息为假设性示例，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*Structural characterization of human C19orf37 and its role in mitochondrial membrane dynamics*
**作者**：Zhang et al., 2020
**摘要**：研究通过重组表达C19orf37蛋白，解析了其晶体结构，揭示其与线粒体内膜结合的机制，并发现该蛋白参与调节线粒体嵴的形态形成。
2. **文献名称**：*C19orf37 interacts with BRCA1 and modulates DNA damage response in cancer cells*
**作者**：Li et al., 2018
**摘要**：该文献利用重组人C19orf37蛋白进行免疫共沉淀实验，证明其与BRCA1蛋白的相互作用，并证实其在DNA损伤修复途径中的潜在功能。
3. **文献名称**：*Expression profiling and functional analysis of C19orf37 in hepatocellular carcinoma*
**作者**：Wang et al., 2021
**摘要**：通过体外重组表达C19orf37.研究发现其在肝癌细胞中高表达，并通过调控Wnt/β-catenin通路促进肿瘤侵袭转移。
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**备注**：实际研究中，C19orf37可能以别名(如HSPC163)出现。建议通过NCBI Gene或UniProt查询最新文献，并优先选择近5年、涉及重组蛋白功能验证的高质量研究。
The human C19orf37 protein, encoded by the chromosome 19 open reading frame 37 gene, remains poorly characterized despite emerging interest in its potential biological roles. This protein is conserved across vertebrates, suggesting functional importance, though its precise molecular mechanisms and cellular functions are not fully elucidated. Structural predictions indicate it may contain an N-terminal transmembrane domain and multiple phosphorylation sites, hinting at involvement in signaling or membrane-associated processes.
Recent studies have linked C19orf37 to diverse physiological contexts. It was identified as a hypoxia-responsive gene in cancer cells, possibly influencing tumor microenvironment adaptation. Additionally, proteomic analyses associate it with cilia function, implying a role in ciliopathies or sensory signaling. Some evidence points to interactions with proteins involved in DNA damage response and mitochondrial metabolism, though these findings require experimental validation.
Recombinant C19orf37 protein (rC19orf37) is typically produced using bacterial or mammalian expression systems, enabling in vitro functional studies and antibody development. Its recombinant form has been utilized in preliminary investigations of protein-protein interactions and subcellular localization, which suggest both cytoplasmic and nuclear distribution. While therapeutic applications remain speculative, ongoing research explores its potential as a biomarker in certain cancers or genetic disorders. Further studies are needed to clarify its physiological ligands, enzymatic activities (if any), and contributions to disease pathways.
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