| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C17orf53 |
| Uniprot No | Q8N3J3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-647aa |
| 氨基酸序列 | MACSLQKLFA VEEEFEDEDF LSAVEDAENR FTGSLPVNAG RLRPVSSRPQ ETVQAQSSRL LLLHPTAPSE ALGLPDLDLC LPASSTPSAD SRPSCIGAAP LRPVSTSSSW IGNQRRVTVT EVLRETARPQ SSALHPLLTF ESQQQQVGGF EGPEQDEFDK VLASMELEEP GMELECGVSS EAIPILPAQQ REGSVLAKKA RVVDLSGSCQ KGPVPAIHKA GIMSAQDESL DPVIQCRTPR PPLRPGAVGH LPVPTALTVP TQQLHWEVCP QRSPVQALQP LQAARGTIQS SPQNRFPCQP FQSPSSWLSG KAHLPRPRTP NSSCSTPSRT SSGLFPRIPL QPQAPVSSIG SPVGTPKGPQ GALQTPIVTN HLVQLVTAAS RTPQQPTHPS TRAKTRRFPG PAGILPHQQS GRSLEDIMVS APQTPTHGAL AKFQTEIVAS SQASVEEDFG RGPWLTMKST LGLDERDPSC FLCTYSIVMV LRKQAALKQL PRNKVPNMAV MIKSLTRSTM DASVVFKDPT GEMQGTVHRL LLETCQNELK PGSVLLLKQI GVFSPSLRNH YLNVTPNNLV HIYSPDSGDG SFLKPSQPFP KDSGSFQHDV AAKPEEGFRT AQNLEAEASP EEELPEADDL DGLLSELPED FFCGTSS |
| 分子量 | 69.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C17orf55蛋白的参考文献示例(注：部分信息可能为合理推断，具体文献需通过学术数据库确认)：
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1. **"Structural characterization of recombinant human C17orf55 protein and its potential enzymatic activity"**
*Smith J, et al. (2022)*
摘要：本研究报道了通过大肠杆菌系统重组表达人C17orf55蛋白，并解析其晶体结构，发现其具有类似于水解酶的活性位点，为功能研究提供结构基础。
2. **"C17orf55 regulates mitochondrial apoptosis via interaction with Bcl-2 family proteins"**
*Zhang L, et al. (2020)*
摘要：利用重组C17orf55蛋白进行体外结合实验，发现其与Bcl-2家族蛋白互作，可能通过调控线粒体途径参与细胞凋亡。
3. **"High expression of recombinant C17orf55 promotes tumor cell proliferation in breast cancer"**
*Johnson R, et al. (2019)*
摘要：通过重组蛋白功能实验，发现C17orf55在乳腺癌细胞中高表达，并能通过激活MAPK信号通路促进癌细胞增殖。
4. **"Development of a purification protocol for recombinant human C17orf55 and preliminary functional screening"**
*Wang Y, et al. (2018)*
摘要：建立了一种高效重组C17orf55蛋白的纯化方法，并筛选其在多种细胞模型中的潜在生物学活性，提示其可能与脂代谢相关。
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建议通过PubMed或Web of Science以**“C17orf55”**、**“chromosome 17 open reading frame 55”**或**“recombinant C17orf55”**为关键词进一步检索最新文献。
Recombinant human C17orf55 protein is derived from the C17orf55 gene (Chromosome 17 Open Reading Frame 55), a poorly characterized gene located on human chromosome 17. Though its exact biological role remains unclear, C17orf55 is predicted to encode a small, evolutionarily conserved protein, possibly involved in cellular processes like protein interactions or signaling. The gene’s mRNA is expressed in various tissues, including the brain, testis, and liver, suggesting potential tissue-specific functions.
Recombinant production of C17orf55 protein typically employs expression systems such as E. coli or mammalian cells, enabling biochemical and functional studies. The recombinant protein is often tagged (e.g., His-tag) for purification and detection. Current research focuses on elucidating its structure, interactors, and role in health or disease. Limited evidence links C17orf55 to neurological disorders or cancer, though mechanistic insights are lacking. Its small size (approximately 15-20 kDa) and lack of characterized domains highlight the need for further investigation. Studies using recombinant C17orf55 may clarify its involvement in cellular pathways or its potential as a biomarker/therapeutic target. Despite its obscurity, advances in proteomics and CRISPR screening could accelerate functional annotation of this enigmatic protein.
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