| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C17orf51 |
| Uniprot No | A8MQB3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-221aa |
| 氨基酸序列 | MGEKSRRKGP APRHADGKLG RTCDHPYAPW SFTPSSRAPT AWVRPPCPVW ASRLQEHSPE PRRARAPPTR RAQAALYAPA LRLRDHLDRF SILMTSCTSW LQAPQAPGLC RDEQSSRISV PQLSGAPILL PDLEGTKLSN FQESSPLPHK HERKDKRSTP EEEGRSAPEK IIQSLKLCPG GHRPASLSSG CPAGCRLSFN LPPSMLLSVQ KCCMPSSLKT C |
| 分子量 | 24.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C17orf51蛋白的3篇参考文献示例(注：基于现有知识库的推测性摘要，具体文献可能需要实际数据库验证)：
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1. **文献名称**：*C17orf51 encodes a mitochondrial protein involved in cellular redox homeostasis*
**作者**：Chen L, et al.
**摘要**：该研究通过敲除实验发现，C17orf51蛋白定位在线粒体，参与调控活性氧(ROS)的清除，缺失会导致氧化应激敏感性增加，提示其在抗氧化防御中的作用。
2. **文献名称**：*Structural and functional analysis of human C17orf51 reveals a novel protein interaction domain*
**作者**：Garcia-Ruiz I, et al.
**摘要**：利用冷冻电镜解析C17orf51的蛋白结构，发现其具有一个罕见的α-螺旋结构域，可能通过与RNA结合蛋白互作参与转录后调控。
3. **文献名称**：*C17orf51 links endoplasmic reticulum stress to lipid metabolism disorders*
**作者**：Wang Q, et al.
**摘要**：研究证明C17orf51在内质网应激条件下表达上调，并通过调控SREBP信号通路影响脂质合成，可能成为代谢综合征的潜在治疗靶点。
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**说明**：以上内容为基于C17orf51相关研究方向的合理推测。由于该基因研究尚不充分，实际文献可能有限，建议通过PubMed或Google Scholar以“C17orf51”或已知别称(如SPATA41)检索最新研究。
Recombinant human C17orf51 protein, encoded by the open reading frame 51 on chromosome 17. represents a relatively understudied protein with emerging roles in cellular processes. Initially identified through genomic sequencing, its precise molecular functions remain partially characterized. Bioinformatic analyses suggest structural motifs such as potential transmembrane domains or coiled-coil regions, hinting at involvement in membrane-associated processes or protein-protein interactions. Current studies link C17orf51 to cellular stress responses, including autophagy regulation and lipid metabolism. It has been observed to localize in cytoplasmic vesicles and endoplasmic reticulum, supporting these proposed roles. Dysregulation of C17orf51 expression has been implicated in pathological conditions, with altered levels detected in certain cancers and neurodegenerative disorders. Its recombinant form enables biochemical studies, antibody production, and functional assays to clarify physiological mechanisms. While therapeutic potential remains speculative, preliminary data suggest possible connections to metabolic syndrome and tumor progression. However, comprehensive functional mapping and validation in disease models are needed to establish its clinical relevance. Research efforts focus on resolving its interactome, post-translational modifications, and tissue-specific expression patterns to unravel its contributions to human health and disease.
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