| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C17orf49 |
| Uniprot No | Q8IXM2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-172aa |
| 氨基酸序列 | MGSSHHHHHH SSGLVPRGSH MGSMTSASTK VGEIFSAAGA AFTKLGELTM QLHPVADSSP AGAKWTETEI EMLRAAVKRF GDDLNHISCV IKERTVAQIK ATVKRKVYED SGIPLPAESP KKGPKKVASG VLSPPPAAPP PSSSSVPEAG GPPIKKQKAD VTLSALNDSD ANSDVVDIEG LGETPPAKKL NFDQA |
| 分子量 | 20 KDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C17orf49蛋白的虚构示例参考文献及摘要概括(仅供示例，非真实文献)：
1. **"Structural characterization of the human C17orf49 protein and its role in cell proliferation"**
- **作者**: Zhang et al., 2021
- **摘要**: 首次解析了C17orf49蛋白的晶体结构，发现其通过结合细胞周期相关激酶CDK2调控细胞增殖。
2. **"Functional analysis of C17orf49 in mitochondrial energy metabolism"**
- **作者**: Lee et al., 2019
- **摘要**: 通过基因敲除实验表明，C17orf49缺失导致线粒体ATP合成障碍，提示其参与能量代谢调控。
3. **"C17orf49 as a potential biomarker in breast cancer progression"**
- **作者**: Rodriguez et al., 2022
- **摘要**: 发现C17orf49在乳腺癌组织中高表达，并通过激活PI3K/AKT通路促进肿瘤侵袭。
4. **"Interaction network of C17orf49 reveals novel partners in DNA repair pathways"**
- **作者**: Kumar et al., 2020
- **摘要**: 利用蛋白质组学技术鉴定出C17orf49与多个DNA损伤修复蛋白相互作用，可能参与基因组稳定性维持。
(注：以上内容为模拟，实际文献需通过PubMed等数据库检索确认。)
**Background of Recombinant Human C17orf49 Protein**
The C17orf49 (Chromosome 17 Open Reading Frame 49) gene, also termed as C16orf87 or MGC45800. encodes a poorly characterized protein conserved across vertebrates. Located on human chromosome 17q25.3. its transcript is ubiquitously expressed, with higher levels in tissues like the thyroid and testes. The protein is small (~15 kDa) and predicted to be intrinsically disordered, lacking stable secondary structures, which complicates functional predictions. However, bioinformatic analyses suggest potential roles in nucleic acid binding or protein-protein interactions.
Studies link C17orf49 to cellular proliferation and apoptosis. Overexpression experiments show it may suppress cell growth in certain cancers, while reduced expression correlates with poor prognosis in hepatocellular carcinoma. It interacts with proteins involved in DNA repair (e.g., PARP1) and cell cycle regulation, hinting at a role in genomic stability.
Despite these clues, its molecular mechanisms remain unclear. No structural data or detailed pathway associations are reported, emphasizing the need for further research. Recombinant C17orf49 proteins are primarily used to study its biochemical properties, interactions, and therapeutic potential, particularly in cancer biology. Current efforts focus on elucidating its physiological relevance and validating its proposed roles in disease.
×
