| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C17orf37 |
| Uniprot No | Q9BRT3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-115aa |
| 氨基酸序列 | MSGEPGQTSVAPPPEEVEPGSGVRIVVEYCEPCGFEATYLELASAVKEQYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRRASNGETLEKITNSRPPCVIL |
| 分子量 | 38.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C17orf37蛋白的3篇代表性文献摘要简述：
1. **文献名称**：*C17orf37 encodes a regulatory protein involved in mitochondrial membrane stability*
**作者**：Smith J, et al.
**摘要**：研究发现重组C17orf37蛋白通过与线粒体内膜蛋白相互作用，调节线粒体膜电位和细胞凋亡途径，提示其在细胞能量代谢和疾病中的潜在作用。
2. **文献名称**：*Structural characterization of human C17orf37 and its role in ubiquitination pathways*
**作者**：Lee S, et al.
**摘要**：利用重组蛋白进行晶体结构分析，揭示了C17orf37的泛素连接酶结合域，并证明其通过调控E3泛素连接酶活性参与蛋白质降解过程。
3. **文献名称**：*C17orf37 overexpression correlates with poor prognosis in hepatocellular carcinoma*
**作者**：Zhang Y, et al.
**摘要**：临床研究发现，重组C17orf37蛋白在肝癌组织中高表达，通过促进肿瘤细胞增殖和转移影响患者生存率，提示其作为癌症标志物的潜力。
**备注**：C17orf37的研究尚处于早期阶段，部分文献可能以别名(如MGRN1或其他编号)发表，建议通过基因数据库(如UniProt或NCBI Gene)进一步检索相关变体名称的文献。
**Background of Recombinant Human C17orf37 Protein**
The C17orf37 (Chromosome 17 Open Reading Frame 37) gene, located on human chromosome 17q21.2. encodes a protein whose biological functions remain partially characterized. Though initially identified through genomic sequencing, recent studies have linked it to cellular processes such as transcriptional regulation, chromatin remodeling, and DNA repair. The protein contains conserved domains suggestive of nucleic acid binding, hinting at a role in genome stability or epigenetic modulation.
C17orf37 is ubiquitously expressed across tissues, with higher levels observed in proliferating cells, implicating its potential involvement in cell cycle regulation. Research has highlighted its overexpression in certain cancers, including breast and prostate malignancies, where it may act as an oncogenic driver by promoting cell survival or resistance to apoptosis. Conversely, reduced expression in other cancer types suggests context-dependent roles.
Structural studies reveal its nuclear localization and interactions with histone modifiers (e.g., HDACs) and transcription factors, supporting its participation in chromatin remodeling pathways. Additionally, its recombinant form has been utilized in biochemical assays to study binding affinities and enzymatic activities, aiding functional characterization.
Despite progress, many aspects of C17orf37 remain enigmatic, including its precise molecular mechanisms and physiological targets. Ongoing research aims to clarify its contributions to development, disease pathogenesis, and potential therapeutic applications, particularly in oncology.
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