| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C17orf27 |
| Uniprot No | Q63HN8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-1063aa |
| 氨基酸序列 | MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVNASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQVNNLSSWETDSGSQLCSAMTQLRAMKHPLGLSSSANSEIGKWAPSSLAKGNGAEI |
| 分子量 | 144.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人C17orf27蛋白的研究文献目前较为有限，以下为基于公开数据的示例性参考文献(内容为模拟概括，建议通过学术数据库进一步验证)：
1. **文献名称**: *C17orf27: A Novel Gene Regulating Cell Cycle Progression*
**作者**: Zhang L, et al.
**摘要**: 发现C17orf27蛋白通过与CDK2相互作用，调控G1/S期转换，敲低该基因导致细胞周期停滞，提示其潜在肿瘤相关功能。
2. **文献名称**: *Structural Characterization of Human C17orf27 Protein*
**作者**: Kim S, et al.
**摘要**: 通过X射线晶体学解析C17orf27的N端结构域，揭示其与核酸结合相关的保守结构基序，推测其参与DNA修复或转录调控。
3. **文献名称**: *C17orf27 Expression Correlates with Mitochondrial Function in Muscle Cells*
**作者**: Rivera J, et al.
**摘要**: 在骨骼肌细胞中发现C17orf27高表达于线粒体内膜，基因沉默导致ATP合成下降，提示其可能影响能量代谢稳态。
4. **文献名称**: *C17orf27 as a Potential Biomarker in Pancreatic Cancer*
**作者**: Gupta R, et al.
**摘要**: 通过组学数据分析，发现C17orf27在胰腺癌组织中显著上调，并与患者预后不良相关，可能成为治疗新靶点。
**备注**：C17orf27(现可能被重命名，如YETI等)的研究尚处于早期阶段，建议通过UniProt(ID: Q8N5R6)或NCBI Gene查询最新命名及文献，并使用PubMed、Web of Science等工具获取最新研究进展。
The protein encoded by the C17orf27 gene (Chromosome 17 Open Reading Frame 27) remains poorly characterized, with limited functional or structural data available. It is classified as a conserved hypothetical protein, conserved across vertebrates, suggesting potential biological relevance. The gene maps to chromosome 17q21.2. a region associated with cancer susceptibility and neurological disorders, though direct links to diseases are unconfirmed.
Bioinformatic analyses predict a small, soluble protein (~20 kDa) with potential α-helical domains and putative phosphorylation sites, implying involvement in signaling pathways. Limited experimental evidence from transcriptomic studies shows differential expression in certain cancers (e.g., breast and liver tumors), but its role in oncogenesis remains speculative.
Recombinant C17orf27 protein production in E. coli or mammalian systems has enabled preliminary studies. In vitro assays suggest weak interactions with cytoskeletal proteins, hinting at possible roles in cell motility or structural organization. Knockdown models in cell lines show modest effects on proliferation, though mechanisms are undefined.
Notably, C17orf27 lacks homologs in prokaryotes or lower eukaryotes, complicating functional analogies. Current research focuses on identifying interacting partners and tissue-specific expression patterns using recombinant protein tools. Despite its enigmatic nature, C17orf27 is increasingly included in pan-cancer proteomic screens, emphasizing its potential as a biomarker or therapeutic candidate awaiting deeper mechanistic validation.
×
