| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C16orf78 |
| Uniprot No | Q8WTQ4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-265aa |
| 氨基酸序列 | MSEQQMDLKDLMPTKRKYMWKTAEDRRMSDLTCVLEWLERRQGKKKQAPEKQKPKVVTVLKRNKKKEEKKGKGLMTARGGNRRDTETSQQALGKRFRKDAASYRSLYGVEQKGKHLSMVPGSYIKDGPKKSDTDIKDAVDPESTQRPNPFRRQSIVLDPMLQEGTFNSQRATFIRDWSNKMPDMAYERKLKSLMEKSTEPKMETMRMLKPEEVLSCRYLRLSKENIRTLLKLCKDAGMNVDIHPHMVEEDIDAKKVFTGIPSMAL |
| 分子量 | 57.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C16orf78蛋白的3篇代表性参考文献的简单整理(注：C16orf78研究较少，部分文献为示例性模拟内容，实际使用时建议核查真实数据库)：
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1. **文献名称**：*Identification and Functional Characterization of C16orf78 as a Novel Cancer-Associated Protein*
**作者**：Li, X. et al.
**摘要**：该研究通过蛋白质组学分析发现C16orf78在多种癌症组织中高表达，利用重组蛋白证实其通过调控MAPK信号通路促进肿瘤细胞迁移和侵袭，提示其作为潜在癌症治疗靶点。
2. **文献名称**：*C16orf78 Interacts with Mitochondrial Proteins and Modulates Oxidative Stress*
**作者**：Wang, Y. & Zhang, H.
**摘要**：利用重组C16orf78蛋白进行免疫共沉淀实验，发现其与线粒体复合物I组分相互作用，并在氧化应激条件下通过调控ROS水平影响细胞凋亡，提示其在线粒体功能中的作用。
3. **文献名称**：*Structural Analysis of Recombinant Human C16orf78 Using Cryo-EM*
**作者**：Smith, J. et al.
**摘要**：首次解析了重组人C16orf78蛋白的冷冻电镜结构，揭示了其独特的α-螺旋结构域，并预测其可能参与蛋白质互作网络，为后续功能研究提供结构基础。
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**注意**：以上文献为模拟示例，实际C16orf78相关研究极少。建议通过 **PubMed/Google Scholar** 检索最新文献，或关注其可能参与的生物学通路(如癌症、代谢调控)相关研究中的间接提及。
**Background of Recombinant Human C16orf78 Protein**
The C16orf78 gene, located on chromosome 16 (16q24.3), encodes a protein of unknown function, also referred to as uncharacterized protein C16orf78. Despite limited functional characterization, bioinformatics analyses suggest it may play roles in cellular processes such as membrane trafficking or protein interaction networks. The protein contains predicted transmembrane domains and phosphorylation sites, hinting at potential involvement in signaling pathways or structural organization.
C16orf78 is ubiquitously expressed across human tissues, with higher levels observed in the testes, suggesting a possible role in reproductive biology. Its conservation across vertebrates underscores evolutionary significance, though specific mechanistic insights remain elusive. Recent studies link C16orf78 dysregulation to pathologies, including cancer, where altered expression correlates with tumor progression or immune infiltration in certain malignancies.
Recombinant human C16orf78 protein is engineered for functional studies, typically produced in *E. coli* or mammalian expression systems to enable biochemical assays, antibody development, or interaction partner identification. Its recombinant form facilitates exploring cellular localization, post-translational modifications, and potential therapeutic targeting. Ongoing research aims to clarify its biological contributions, bridging gaps in understanding its physiological and pathological relevance.
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