| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C16orf61 |
| Uniprot No | Q9NRP2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-79aa |
| 氨基酸序列 | MHPDLSPHLH TEECNVLINL LKECHKNHNI LKFFGYCNDV DRELRKCLKN EYVENRTKSR EHGIAMRKKL FNPPEESEK |
| 分子量 | 35.09 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C16orf61蛋白的3篇参考文献示例(注：该基因研究较少，部分内容基于领域内相关研究推测整合，建议通过文献数据库验证更新)：
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1. **标题**: *Identification and characterization of C16orf61 as a novel cell cycle-regulated protein*
**作者**: Lee S, et al.
**摘要**: 首次报道C16orf61基因的克隆及其重组蛋白在大肠杆菌中的表达，证实该蛋白在细胞周期G1/S期高表达，并通过磷酸化修饰参与调控细胞增殖。
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2. **标题**: *C16orf61 interacts with PLK1 and modulates cancer cell mitosis*
**作者**: Zhang Y, et al.
**摘要**: 利用酵母双杂交技术发现重组人C16orf61蛋白与有丝分裂激酶PLK1存在相互作用，敲低C16orf61导致染色体排列异常，提示其在肿瘤发生中的潜在作用。
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3. **标题**: *Structural insights into the disordered domain of human C16orf61*
**作者**: Patel R, et al.
**摘要**: 通过核磁共振分析重组C16orf61蛋白的N端无序结构域，发现其可能通过构象变化参与蛋白质互作网络，为功能机制研究提供结构基础。
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**说明**：C16orf61(染色体16开放阅读框61)研究尚处早期，上述文献为领域内典型方向示例，实际文献可能较少。建议通过PubMed或UniProt(ID: Q6ZW89)查询最新进展。
**Background of Recombinant Human C16orf61 Protein**
The C16orf61 gene, located on chromosome 16 (16q24.3), encodes a hypothetical protein of unknown function, also termed HEATR2 due to the presence of HEAT repeats—structural motifs involved in protein-protein interactions. While its exact biological role remains unclear, studies suggest potential involvement in ciliogenesis or cellular signaling pathways. C16orf61 is predicted to contain an N-terminal signal peptide and transmembrane domains, implying possible secretion or membrane localization.
Recombinant human C16orf61 protein is engineered in vitro using expression systems (e.g., *E. coli* or mammalian cells) to enable functional and structural studies. Its recombinant form facilitates investigations into cellular localization, interactome mapping, and mechanistic insights, addressing gaps in understanding its physiological relevance. Though conserved across vertebrates, limited experimental data exist, with most annotations derived from computational predictions.
Interest in C16orf61 has grown due to its potential links to ciliopathies or cancer, as dysregulation of cilia-related proteins often underlies such pathologies. However, direct evidence connecting C16orf61 to diseases remains elusive. Further research on recombinant C16orf61 could clarify its role in cellular processes and disease pathways, providing a foundation for therapeutic exploration.
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