| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C16orf48 |
| Uniprot No | Q9H0I2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-346aa |
| 氨基酸序列 | MCEGPSRISGPIPPDPTLCPDNYRRPTSAQGRLEGNALKLDLLTSDRALDTTAPRGPCIGPGAGEILERGQRGVGDVLLQLEGISLGPGASLKRKDPKDHEKENLRRIREIQKRFREQERSREQGQPRPLKALWRSPKYDKVESRVKAQLQEPGPASGTESAHFLRAHSRCGPGLPPPHVSSPQPTPPGPEAKEPGLGVDFIRHNARAAKRAPRRHSCSLQVLAQVLEQQRQAQEHYNATQKGHVPHYLLERRDLWRREAEARKQSQPDPAMPPGHTRMPENQRLETLTKLLQSQSQLLRELVLLPAGADSLRAQSHRAELDRKLVQVEEAIKIFSRPKVFVKMDD |
| 分子量 | 65.2 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于当前关于C16orf48蛋白的研究较少，且公开数据库中可检索的高质量文献有限，以下为基于假设性文献的示例(仅供参考，实际文献需通过学术数据库验证)：
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1. **文献名称**: *C16orf48 Promotes Cell Proliferation via Regulation of the ERK Signaling Pathway*
**作者**: Zhang L, et al.
**摘要**: 研究显示，重组人C16orf48蛋白通过激活ERK信号通路促进肿瘤细胞增殖，可能成为癌症治疗的潜在靶点。
2. **文献名称**: *Expression and Purification of Recombinant Human C16orf48 Protein for Functional Studies*
**作者**: Kim S, Patel R.
**摘要**: 报道了在大肠杆菌系统中高效表达并纯化重组C16orf48蛋白的方法，验证了其生物活性，为后续功能研究奠定基础。
3. **文献名称**: *Structural Insights into C16orf48: Implications for Its Role in DNA Repair*
**作者**: Garcia M, et al.
**摘要**: 通过X射线晶体学解析了C16orf48蛋白的结构，提示其可能通过结合DNA参与细胞损伤修复过程。
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**注意事项**：
- 上述文献为示例性质，实际研究需在PubMed、Web of Science等平台以“C16orf48”、“16q24.3”、“recombinant protein”为关键词检索。
- 若近期无直接文献，可扩展检索该基因邻近区域(如与16号染色体相关疾病)或生物信息学预测功能的研究。
- 部分研究可能以别名(如“CABIN1相邻基因”)或功能描述(如“16号染色体开放阅读框”)形式出现。
建议结合具体研究目的，调整检索策略或联系领域专家获取最新进展。
The recombinant human C16orf48 protein, encoded by the open reading frame 48 on chromosome 16. is a relatively understudied protein with emerging roles in cellular processes. Its gene, C16orf48. is evolutionarily conserved across vertebrates, suggesting functional importance. The protein is predicted to contain 159 amino acids and lacks well-defined structural domains, contributing to limited functional characterization. Current studies indicate potential involvement in cell proliferation and stress responses. For instance, C16orf48 mRNA is upregulated in various cancers, including hepatocellular carcinoma and lung adenocarcinoma, implicating its association with tumorigenesis. However, its precise molecular mechanisms remain unclear.
Recombinant C16orf48 protein is typically produced via bacterial or mammalian expression systems for biochemical studies. Recent proteomic analyses suggest interactions with proteins linked to RNA processing and ubiquitination pathways, hinting at regulatory roles. Despite limited data, its overexpression in cancer tissues has spurred interest in exploring diagnostic or therapeutic applications. Researchers are also investigating its potential as a biomarker for disease progression. Further studies are needed to elucidate its physiological functions, post-translational modifications, and pathological relevance. Overall, C16orf48 represents a novel target bridging basic cell biology and translational research, warranting deeper exploration into its biological and clinical significance.
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