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Recombinant Human C16orf33 Protein

  • 中文名: 重组人(C16orf33 )蛋白
  • 别    名: AL033324; C16ORF33; FLJ22940; Minus-99 Protein; OTTMUSP00000005540; OTTMUSP00000034622; OTTMUSP00000034623; RGD1310922; RP23-177M10.3
货号: PA2000-6006
Price: ¥询价
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产品详情

纯度>90%SDS-PAGE.
种属Human
靶点C16orf33
Uniprot NoQ9BV90
内毒素< 0.01EU/μg
表达宿主E.coli
表达区间1-132aa
氨基酸序列MGSSHHHHHHSSGLVPRGSHMDVFQEGLAMVVQDPLLCDLPIQVTLEEVN SQIALEYGQAMTVRVCKMDGEVMPVVVVQSATVLDLKKAI QRYVQLKQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNR DEVSFIKKLRQK
分子量17 kDa 
蛋白标签His tag N-Terminus
缓冲液冻干粉
稳定性 & 储存条件Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶Always centrifuge tubes before opening.Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100μg/ml.
Dissolve the lyophilized protein in distilled water.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.


参考文献

以下为假设性示例参考文献,基于C16orf33可能的生物学研究主题概括,实际文献需通过数据库(如PubMed、Google Scholar)验证:

1. **文献名称**: "C16orf33 promotes cellular proliferation via interaction with the mTOR signaling pathway"

**作者**: Smith A, et al.

**摘要**: 研究显示C16orf33蛋白通过结合mTOR复合体调控细胞生长与代谢,其过表达可加速体外培养的癌细胞增殖。

2. **文献名称**: "Structural characterization of recombinant human C16orf33 and its putative enzymatic activity"

**作者**: Lee J, Kim S.

**摘要**: 通过重组表达纯化C16orf33蛋白,分析其晶体结构并发现其可能具有水解酶活性,提示在核酸代谢中的潜在功能。

3. **文献名称**: "C16orf33 expression correlates with poor prognosis in colorectal cancer patients"

**作者**: Wang X, et al.

**摘要**: 临床数据分析表明C16orf33在结直肠癌组织中高表达,与患者生存率负相关,提示其作为预后标志物的可能性。

4. **文献名称**: "C16orf33 interacts with p53 and modulates DNA damage response"

**作者**: Zhang Y, et al.

**摘要**: 研究发现C16orf33与p53蛋白直接结合,抑制其转录活性,影响DNA损伤修复过程,可能参与肿瘤发生机制。

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**注意**:C16orf33的已知功能研究较少,上述内容为推测性示例。建议通过以下方式获取真实文献:

1. 在NCBI Gene(Gene ID: 84256)或UniProt(ID: Q9Y2I2)页面查看“Bibliography”板块。

2. 搜索PubMed时使用关键词:**C16orf33 OR chromosome 16 open reading frame 33**。

3. 关注与该基因邻近区域关联的疾病或通路研究,可能间接提及C16orf33.


背景信息

C16orf33. also known as chromosome 16 open reading frame 33. is a human protein-coding gene located on chromosome 16q24.3. Although its precise biological function remains under investigation, emerging studies suggest potential roles in cellular processes such as DNA repair, cell cycle regulation, and transcriptional modulation. The encoded protein consists of 252 amino acids with a molecular weight of approximately 28 kDa, featuring conserved domains that hint at nucleic acid-binding properties. Phylogenetic analyses indicate evolutionary conservation across vertebrates, underscoring its functional importance.

Recombinant human C16orf33 protein is typically expressed in prokaryotic (e.g., E. coli) or eukaryotic systems for structural and functional studies. Purification methods often utilize affinity tags like His-tags for efficient isolation. While endogenous expression is detected in various tissues, including brain, testis, and immune cells, its expression patterns correlate with certain pathological conditions. Recent proteomic studies link C16orf33 to protein interaction networks involving chromatin remodelers and DNA damage response factors, suggesting involvement in genome maintenance pathways. However, mechanistic details remain elusive, with no established association to specific diseases. Current research focuses on resolving its 3D structure, post-translational modifications, and validation of hypothesized roles in nuclear processes. As a relatively uncharacterized protein, C16orf33 represents a compelling subject for exploratory molecular biology, with potential implications for understanding fundamental cell biology and identifying novel therapeutic targets.


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