| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C15orf57 |
| Uniprot No | Q9BV29 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-185aa |
| 氨基酸序列 | MKMFESADSTATRSGQDLWAEICSCLPNPEQEDGANNAFSDSFVDSCPEGEGQREVADFAVQPAVKPWAPLQDSEVYLASLEKKLRRIKGLNQEVTSKDMLRTLAQAKKECWDRFLQEKLASEFFVDGLDSDESTLEHFKRWLQPDKVAVSTEEVQYLIPPESQVEKPVAEDEPAAGDKPAAAEQ |
| 分子量 | 47.1 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于现有知识推测的假设性文献示例，用于说明可能的C15orf57相关研究方向。请注意，这些并非真实存在的文献，实际研究请通过PubMed、Google Scholar等数据库检索：
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1. **文献名称**：*UCC57 regulates mitotic spindle integrity through interaction with PLK1*
**作者**：Lee et al. (2022)
**摘要**：研究发现C15orf57(UCC57)通过与有丝分裂激酶PLK1相互作用，维持纺锤体组装和染色体正确分离，其缺失导致基因组不稳定和细胞周期停滞。
2. **文献名称**：*C15orf57 deficiency links to impaired DNA repair in colorectal cancer*
**作者**：Zhang et al. (2021)
**摘要**：该研究揭示C15orf57在结直肠癌细胞中调控DNA损伤修复通路，低表达与放疗耐药性相关，机制可能涉及与RAD51复合物的协同作用。
3. **文献名称**：*Systematic analysis of C15orf57 expression across human tissues*
**作者**：Global Proteome Database Consortium (2020)
**摘要**：通过蛋白质组学分析，报道C15orf57在睾丸、淋巴组织等高增殖器官中高表达，提示其在细胞增殖中的潜在功能。
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**建议**：查阅真实文献时，可使用关键词如 **C15orf57**、**UCC57**、**chromosome 15 open reading frame 57** 结合相关功能(如 **mitosis**、**DNA repair**)在学术数据库中检索。已知C15orf57在UniProt中的编号为Q8N6C5.可参考其条目下的引用文献。
**Background of Human Recombinant C15orf57 Protein**
The human C15orf57 protein, also known as FAM189A2 or CABIN1. is encoded by the *C15orf57* gene located on chromosome 15q22.31. Though its exact molecular mechanisms remain incompletely characterized, emerging studies suggest its involvement in critical cellular processes, including cell cycle regulation, DNA damage response, and epigenetic modulation. C15orf57 is reported to localize predominantly in the nucleus and interact with protein complexes such as HDAC (histone deacetylase) complexes, hinting at a potential role in chromatin remodeling and transcriptional regulation.
Structurally, C15orf57 contains intrinsically disordered regions and conserved motifs linked to protein-protein interactions, including coiled-coil domains and nuclear localization signals. Expression profiling shows broad tissue distribution, with higher levels observed in the testis, skeletal muscle, and specific brain regions, implying tissue-specific functions. Recent studies associate C15orf57 dysregulation with pathological conditions, particularly cancers (e.g., glioblastoma, colorectal carcinoma) where aberrant expression correlates with tumor progression or survival. It has also been proposed as a candidate gene for neurodevelopmental or reproductive disorders, though mechanistic insights remain limited.
Despite its unclear physiological role, C15orf57’s conserved presence across vertebrates and interaction networks with key regulatory proteins underscore its biological significance. Further investigations are needed to unravel its precise functions and therapeutic potential.
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