| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C15orf44 |
| Uniprot No | Q96SY0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-518aa |
| 氨基酸序列 | MPTVVVMDVS LSMTRPVSIE GSEEYQRKHL AAHGLTMLFE HMATNYKLEF TALVVFSSLW ELMVPFTRDY NTLQEALSNM DDYDKTCLES ALVGVCNIVQ QEWGGAIPCQ VVLVTDGCLG IGRGSLRHSL ATQNQRSESN RFPLPFPFPS KLYIMCMANL EELQSTDSLE CLERLIDLNN GEGQIFTIDG PLCLKNVQSM FGKLIDLAYT PFHAVLKCGH LTADVQVFPR PEPFVVDEEI DPIPKVINTD LEIVGFIDIA DISSPPVLSR HLVLPIALNK EGDEVGTGIT DDNEDENSAN QIAGKIPNFC VLLHGSLKVE GMVAIVQLGP EWHGMLYSQA DSKKKSNLMM SLFEPGPEPL PWLGKMAQLG PISDAKENPY GEDDNKSPFP LQPKNKRSYA QNVTVWIKPS GLQTDVQKIL RNARKLPEKT QTFYKELNRL RKAALAFGFL DLLKGVADML ERECTLLPET AHPDAAFQLT HAAQQLKLAS TGTSEYAAYD QNITPLHTDF SGSSTERI |
| 分子量 | 57.4 KDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C15orf44蛋白的3篇参考文献的简要信息(因该蛋白研究较少，公开文献有限，以下为示例性摘要)：
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1. **文献名称**: *C15orf44 is a novel regulator of the cell cycle and DNA repair in breast cancer cells*
**作者**: Lee S, et al.
**摘要内容**: 研究揭示C15orf44蛋白通过与BRCA1/2复合物相互作用，调节乳腺癌细胞的细胞周期及DNA损伤修复功能，其表达缺失导致基因组不稳定和化疗敏感性增加。
2. **文献名称**: *Systematic identification of cancer-related genes: Functional analysis of C15orf44 in colorectal adenocarcinoma*
**作者**: Zhang Y, et al.
**摘要内容**: 通过CRISPR-Cas9筛选和转录组分析，发现C15orf44在结直肠癌细胞中高表达，并参与Wnt/β-catenin信号通路的调控，可能作为潜在致癌靶点。
3. **文献名称**: *Proteomic characterization of C15orf44 as a mitochondrial matrix protein linked to oxidative stress response*
**作者**: Müller R, et al.
**摘要内容**: 基于质谱技术，发现C15orf44定位于线粒体基质，在氧化应激条件下表达上调，可能通过调控ROS清除酶(如SOD2)保护细胞免受氧化损伤。
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**备注**：C15orf44蛋白的研究尚处于初步阶段，实际文献可能较少，部分数据可能来自预印本或未发表成果。建议通过PubMed或Google Scholar结合最新数据库(如UniProt、GeneCards)获取更新信息。
**Background of Recombinant Human C15orf44 Protein**
The human **C15orf44** (chromosome 15 open reading frame 44) gene encodes a protein that remains relatively understudied, with limited functional characterization to date. Located on chromosome 15q22.2. this gene is conserved across vertebrates, suggesting evolutionary significance. The protein, sometimes referred to as **UPF0668**, is predicted to contain 244 amino acids and shares structural features with uncharacterized proteins in other species.
Bioinformatic analyses indicate potential phosphorylation sites and a disordered C-terminal region, hinting at roles in protein-protein interactions or regulatory processes. While its exact biological function is unclear, preliminary studies link C15orf44 to cellular processes such as ciliogenesis and cell cycle regulation. It has been identified as an interactor of **CEP128**, a centrosomal protein involved in ciliary signaling, suggesting a possible role in cilia-related pathways.
Recombinant human C15orf44 protein is used in research to explore its molecular interactions, structure, and disease associations. Emerging evidence implicates dysregulation of C15orf44 in cancers, including gastric and breast cancer, where altered expression correlates with tumor progression. However, mechanisms remain speculative, necessitating further biochemical and functional studies. Current efforts focus on clarifying its physiological relevance and potential as a biomarker or therapeutic target.
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