关键信息
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基因名
IL-20R2
- 应用
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别名
IL-20R2；DIRS1；Interleukin-20 receptor subunit beta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6UXL0
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表达区间
30-233aa
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氨基酸序列
DEVAILPAPQNLSVLSTNMKHLLMWSPVIAPGETVYYSVEYQGEYESLYTSHIWIPSSWCSLTEGPECDVTDDITATVPYNLRVRATLGSQTSAWSILKHPFNRNSTILTRPGMEITKDGFHLVIELEDLGPQFEFLVAYWRREPGAEEHVKMVRSGGIPVHLETMEPGAAYCVKAQTFVKAIGRYSAFSQTECVEVQGEAIPL
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分子量
29.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
IL-20R2, or Interleukin-20 Receptor subunit 2, is a member of the type II cytokine receptor family, playing a crucial role in immune responses and inflammatory processes. Its significance has been increasingly recognized in various diseases, including autoimmune disorders and skin conditions like psoriasis, where IL-20R2 mediates the effects of IL-20 and IL-24, cytokines implicated in inflammation and keratinocyte activities. Research has shown that IL-20R2 is primarily expressed in epithelial tissues, suggesting its involvement in the regulation of mucosal immunity and skin homeostasis. The development of recombinant IL-20R2 proteins has become essential for understanding its biological functions and potential therapeutic applications. These proteins facilitate the study of receptor-ligand interactions, signal transduction pathways, and the receptor's role in modulating immune responses. Furthermore, recombinant IL-20R2 can serve as a valuable tool in drug development, potentially leading to novel treatments for inflammatory and autoimmune diseases. As researchers continue to explore its mechanisms, the characterization of IL-20R2 remains a promising area of investigation that may yield significant insights into immune regulation and pave the way for innovative therapeutic strategies.
