关键信息
-
基因名
CXCR4
- 应用
-
别名
(CXC-R4)(CXCR-4)(FB22)(Fusin)(HM89)(LCR1)(Leukocyte-derived seven transmembrane domain receptor)(LESTR)(Lipopolysaccharide-associated protein 3)(LAP-3)(LPS-associated protein 3)(NPYRL)(Stromal cell-derived factor 1 receptor)(SDF-1 receptor)(CD antigen CD184)
-
种属
Human
-
表达系统
HEK293
-
标签
C- His (This can be tested only under denaturing conditions)
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P61073
-
表达区间
1-352aa
-
蛋白长度
Partial
-
分子量
41.5 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CXCR4, a chemokine receptor also known as C-X-C chemokine receptor type 4, plays a pivotal role in immune response, cell migration, and various physiological processes. It is primarily recognized for its involvement in HIV entry into host cells, making it a critical target for therapeutic intervention in HIV/AIDS. Recent studies have highlighted the role of CXCR4 in numerous other pathological conditions, including cancer metastasis, where its overexpression is associated with poor prognosis and increased tumor spread. The receptor is involved in several cellular signaling pathways that influence not just immune cell trafficking, but also the behavior of cancer cells and the tumor microenvironment. As a result, the development of CXCR4 recombinant proteins has gained significance for both basic research and clinical applications. These proteins can be utilized as research tools to better understand CXCR4 signaling mechanisms, facilitate drug development, and explore potential therapeutic agents that can block CXCR4 functionality. Additionally, the production of CXCR4 recombinant proteins can aid in the design of specific inhibitors that target this receptor, providing new avenues for treatment in various diseases, including cancer and viral infections. Understanding the structure, function, and interactions of CXCR4 through recombinant technology may reveal crucial insights into disease mechanisms and open doors for novel therapeutic strategies. Overall, the exploration of CXCR4 recombinant proteins represents a promising frontier in biomedical research with potential applications in immunology, oncology, and virology.
