| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | PCP; HUMPCP |
| WB Predicted band size | 56 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PRCP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于SOCS2抗体的参考文献摘要(示例基于典型研究主题，具体文献需根据实际查询结果调整)：
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1. **文献名称**: *SOCS2 regulates proliferation and stem cell-like features in breast cancer cells*
**作者**: Smith A, et al.
**摘要**: 本研究利用SOCS2特异性抗体进行Western blot和免疫荧光分析，发现SOCS2通过抑制STAT3磷酸化抑制乳腺癌细胞增殖和干细胞特性，提示其作为潜在治疗靶点。
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2. **文献名称**: *SOCS2 deficiency promotes hepatic steatosis via JAK/STAT pathway dysregulation*
**作者**: Chen L, et al.
**摘要**: 通过SOCS2抗体在小鼠肝脏组织中的免疫组化检测，作者发现SOCS2缺失导致JAK/STAT信号异常激活，进而促进脂质积累和非酒精性脂肪肝的发展。
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3. **文献名称**: *SOCS2 antibody-based biomarker panel for early colorectal cancer detection*
**作者**: Kim Y, et al.
**摘要**: 研究开发了一种基于SOCS2抗体的ELISA检测方法，结合其他标志物，显著提高了早期结直肠癌的诊断灵敏性，验证了SOCS2在血清中的异常表达与肿瘤进展相关。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“SOCS2 antibody”或“SOCS2 function”筛选近五年研究。
The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family, which comprises intracellular proteins that regulate cytokine signaling pathways by inhibiting Janus kinase (JAK)-signal transducer and activator of transcription (STAT) cascades. SOCS2 specifically acts as a negative feedback regulator, controlling cellular responses to growth hormone, prolactin, and various cytokines. Structurally, it contains a central SH2 domain for binding phosphorylated tyrosine residues and a C-terminal SOCS box that mediates protein degradation via ubiquitination. Dysregulation of SOCS2 has been implicated in immune disorders, cancer, and metabolic diseases, making it a research focus for therapeutic targeting.
SOCS2 antibodies are essential tools for studying its expression, localization, and function in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect SOCS2 protein levels in tissues or cell lines. Researchers also employ them to explore SOCS2's role in disease mechanisms, such as its tumor-suppressive or oncogenic effects in different cancers. Commercial SOCS2 antibodies are typically validated for specificity and sensitivity, with some targeting specific epitopes or post-translational modifications. Their applications extend to preclinical studies evaluating SOCS2 as a biomarker or therapeutic target in inflammatory conditions and malignancies.
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