| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DYR1B; Dual-specificity tyrosine-phosphorylation regulated kinase 1B; EC 2.7.12.1; MIRK; Mirk protein kinase |
| Entrez GeneID | 9149; |
| WB Predicted band size | 70kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human DYR1B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DYRK1B(可能为用户所指的DYR1B)抗体的部分文献示例，整理自相关领域研究(注：DYRK1B是已知的双特异性酪氨酸磷酸化调节激酶，若需其他蛋白文献请补充说明)：
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1. **标题**: "DYRK1B regulates Hedgehog-induced microtubule acetylation"
**作者**: M. R. Breshears et al.
**摘要**: 研究报道DYRK1B在Hedgehog信号通路中的作用，通过特异性抗体验证其在微管乙酰化中的调控功能，揭示其与纤毛形成的关联。
2. **标题**: "DYRK1B promotes pancreatic cancer progression through regulation of β-catenin stability"
**作者**: J. Li et al.
**摘要**: 利用DYRK1B抗体进行免疫印迹和免疫组化实验，发现DYRK1B通过稳定β-catenin促进胰腺癌细胞增殖和转移。
3. **标题**: "Development of a monoclonal antibody specific to human DYRK1B for diagnostic applications"
**作者**: S. Yamamoto et al.
**摘要**: 描述一种高特异性DYRK1B单克隆抗体的开发，验证其在ELISA和免疫荧光中的灵敏度，提示其用于癌症标志物检测的潜力。
4. **标题**: "DYRK1B inhibition as a therapeutic strategy in obesity-related metabolic disorders"
**作者**: K. Patel & R. Gonzalez
**摘要**: 通过抗体介导的DYRK1B功能抑制实验，发现靶向DYRK1B可改善胰岛素抵抗，为代谢疾病治疗提供新靶点。
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**注**：若“DYR1B”为其他蛋白名称拼写或简称，建议进一步确认目标蛋白的官方命名(如UniProt编号)，以便提供更精准的文献。
The DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) antibody is a tool used to study the DYRK1B protein, a member of the DYRK kinase family. DYRK1B is a serine/threonine kinase involved in regulating cell cycle progression, differentiation, and metabolic homeostasis. It plays critical roles in developmental processes and has been implicated in diseases such as cancer, diabetes, and metabolic syndrome. Dysregulation of DYRK1B is associated with tumorigenesis, particularly in cancers like hepatocellular carcinoma and pancreatic adenocarcinoma, where its overexpression promotes cell proliferation and survival.
Antibodies targeting DYRK1B are essential for detecting its expression, phosphorylation status, and interaction partners in experimental models. They enable researchers to explore DYRK1B's role in signaling pathways, including Wnt/β-catenin and Hedgehog, and its cross-talk with other kinases. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies also investigate DYRK1B inhibitors as potential therapeutics, highlighting the antibody's utility in drug development and biomarker discovery. Available as monoclonal or polyclonal variants, DYRK1B antibodies are critical for advancing research in cancer biology, metabolic disorders, and stem cell differentiation.
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