| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Y-box-binding protein 2; Germ cell-specific Y-box-binding protein; Contrin; MSY2 homolog; YBX2 |
| Entrez GeneID | 51087; |
| WB Predicted band size | 38kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human YBOX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于YBOX2抗体的3篇参考文献的简要信息：
1. **文献名称**：*The role of YBX2 in mRNA stabilization during oocyte development*
**作者**：Guo et al.
**摘要**：研究利用特异性YBX2抗体，通过免疫沉淀和Western blot分析，揭示了YBX2在小鼠卵母细胞中通过结合特定mRNA序列调控其稳定性和翻译的机制。
2. **文献名称**：*Development of a monoclonal antibody targeting human YBX2 for cancer biomarker studies*
**作者**：Tanaka et al.
**摘要**：报道了一种高特异性抗人YBX2单克隆抗体的开发，验证其在免疫组化中的应用，并发现YBX2在乳腺癌组织中高表达，提示其作为预后标志物的潜力。
3. **文献名称**：*YBX2 regulates spermatogenesis by controlling mRNA storage in male germ cells*
**作者**：Yang et al.
**摘要**：通过免疫荧光和基因敲除模型，结合抗YBX2抗体的使用，证明YBX2在精子形成过程中通过调控mRNA存储和翻译维持生殖细胞发育的功能。
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**备注**：以上文献为模拟示例，实际文献需通过PubMed或Google Scholar检索关键词(如“YBX2 antibody”“Y-box binding protein 2”)获取。
**Background of YBOX2 Antibody**
YBOX2. also known as Y-box binding protein 2 (YBX2), is a member of the Y-box protein family characterized by a conserved cold shock domain (CSD) that binds RNA and DNA. It plays critical roles in transcriptional and post-transcriptional regulation, particularly in germ cell development, spermatogenesis, and early embryogenesis. YBX2 is highly expressed in reproductive tissues, where it stabilizes and transports mRNA, ensuring proper protein synthesis during gametogenesis and embryonic patterning.
Antibodies targeting YBX2 are essential tools for studying its expression, localization, and functional mechanisms. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate YBX2's involvement in cellular processes such as RNA metabolism, stress response, and cell differentiation. Dysregulation of YBX2 has been linked to reproductive disorders and cancers, making its detection crucial for understanding disease pathways.
Developed against specific epitopes (e.g., N-terminal or CSD regions), YBX2 antibodies vary in host species (rabbit, mouse) and clonality (monoclonal/polyclonal). Validation includes testing in knockout models or siRNA-treated samples to confirm specificity. Their application in research continues to shed light on YBX2's dual roles in gene regulation and its potential as a therapeutic target.
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