Cat: PA1000-1583

Recombinant Human IL-1 Protein,His

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关键信息

  • 基因名

    IL-1

  • 应用

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    IL37;FIL1Z;IL1F7;IL1H4;Interleukin-37

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P01584

  • 表达区间

    117-269aa

  • 氨基酸序列

    APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS

  • 分子量

    17 kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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背景信息

Interleukin-1 (IL-1) is a key pro-inflammatory cytokine involved in various immune responses, playing a crucial role in the pathogenesis of numerous diseases, including autoimmune disorders, inflammatory diseases, and cancer. Research on recombinant IL-1 proteins has gained significant attention due to their potential therapeutic applications. IL-1 exists in two main forms, IL-1α and IL-1β, both of which are synthesized as inactive precursors and require proteolytic cleavage for their activity. Investigating recombinant IL-1 proteins enables scientists to explore their biological functions, mechanisms of action, and signaling pathways, thereby advancing our understanding of inflammation and immune regulation. Furthermore, recombinant IL-1 proteins are valuable tools for studying the effects of this cytokine in vitro and in vivo, allowing for the development of novel therapies aiming to modulate IL-1 activity. For instance, IL-1 antagonists, such as anakinra, have already shown promise in treating conditions like rheumatoid arthritis. The exploration of IL-1's role in various diseases has also led to the identification of IL-1 as a potential target for immunotherapy, highlighting its importance in the evolving landscape of disease treatment strategies. Overall, the study of recombinant IL-1 proteins holds significant potential for advancing both basic and clinical research, providing insights that may translate into innovative therapeutic approaches.

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