Rabbit Polyclonal DSCR1(Phospho-Ser108) Antibody

The DSCR1 (Down Syndrome Critical Region Gene 1) protein, also known as RCAN1 (Regulator of Calcineurin 1), is encoded by a gene located on chromosome 21. It plays a regulatory role in calcineurin-mediated signaling pathways, influencing processes like angiogenesis, cardiac development, and stress responses. Phosphorylation at specific residues, such as Ser108. modulates its function by altering interactions with calcineurin or other binding partners. The DSCR1 (Phospho-Ser108) antibody is a specialized tool designed to detect the phosphorylated form of DSCR1 at serine residue 108. a post-translational modification linked to cellular responses under oxidative or inflammatory conditions. This antibody is widely used in research to study DSCR1's role in pathological contexts, including Down syndrome-related complications, Alzheimer’s disease, and cardiovascular disorders. Its applications span techniques like Western blotting, immunofluorescence, and immunohistochemistry, enabling precise localization and quantification of phosphorylated DSCR1 in tissues or cell lines. Understanding DSCR1 phosphorylation dynamics aids in elucidating its contribution to calcineurin signaling dysregulation, offering insights into therapeutic targets for diseases associated with altered kinase/phosphatase activity.