首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal CaseinKinaseIIβ(Phospho-Ser209) Antibody

  • 中文名： Casein Kinase IIβ (Phospho-Ser209)抗体
  • 别    名： CSNK2B; CK2N; G5A; Casein kinase II subunit beta; CK II beta; Phosvitin; Protein G5a
货号: IPDX40921
Price： ￥1280
数量：
大包装询价

验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/300 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/40000 Human,Mouse,Rat

产品详情

AliasesCSNK2B; CK2N; G5A; Casein kinase II subunit beta; CK II beta; Phosvitin; Protein G5a
Entrez GeneID1460;
WB Predicted band size25kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenSynthesized peptide derived from human Casein Kinase IIβ around the phosphorylation site of S209.
FormulationPurified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

+ +

参考文献

以下是关于Casein Kinase IIβ (Phospho-Ser209)抗体的3篇参考文献的简要总结：

1. **文献名称**: *"Phosphorylation of Casein Kinase IIβ at Ser209 promotes tumorigenesis through regulating cell cycle progression"*

**作者**: Zhang Y, et al.

**摘要**: 研究揭示了CK2β Ser209磷酸化通过调控细胞周期蛋白表达(如Cyclin D1)促进肿瘤细胞增殖，并利用Phospho-Ser209抗体验证了该位点在多种癌症模型中的异常激活。

2. **文献名称**: *"Structural basis of CK2β regulatory subunit recognition by phosphorylation-specific antibodies"*

**作者**: Guerra B, Litchfield DW.

**摘要**: 通过晶体学分析CK2β的磷酸化表位，证实Phospho-Ser209抗体的特异性，并应用于检测细胞有丝分裂过程中CK2β的构象变化。

3. **文献名称**: *"Casein kinase IIβ phosphorylation at Ser209 modulates substrate interactions in DNA damage response"*

**作者**: Hériché JK, et al.

**摘要**: 研究发现CK2β Ser209磷酸化影响其与p53等底物的结合，Phospho-Ser209抗体被用于ChIP实验，证明该修饰在DNA损伤修复中的时空调控作用。

(注：上述文献为示例性内容，实际引用需根据具体研究检索PubMed、Google Scholar等数据库获取。)

背景信息

Casein Kinase IIβ (CK2β) Phospho-Ser209 antibody is a phosphospecific antibody designed to detect the β-subunit of Casein Kinase II (CK2) when phosphorylated at serine residue 209. CK2 is a ubiquitously expressed serine/threonine kinase composed of two catalytic subunits (α/α') and two regulatory β-subunits. The β-subunit plays a regulatory role, stabilizing the holoenzyme complex, modulating substrate specificity, and influencing subcellular localization. Phosphorylation at Ser209 in CK2β is a post-translational modification implicated in regulating CK2 activity and interactions with cellular partners. This site lies within the acidic loop region of CK2β, and its phosphorylation may influence CK2 holoenzyme assembly, substrate recruitment, or protein-protein interactions. The antibody is commonly used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to study CK2β phosphorylation dynamics in cellular processes such as cell cycle regulation, DNA repair, and apoptosis. Dysregulation of CK2 activity, including phosphorylation-dependent mechanisms, has been linked to cancer, neurodegenerative diseases, and viral infections, making this antibody a valuable tool for investigating CK2-related signaling pathways and disease mechanisms. Specificity for the phosphorylated form ensures accurate detection of activated CK2β in biological samples.

客户数据及评论

折叠内容

大包装询价

×