Rabbit Polyclonal PAKγ(Phospho-Ser20) Antibody

The PAKγ (Phospho-Ser20) antibody is a specialized tool used to detect the activated form of p21-activated kinase gamma (PAKγ), a serine/threonine kinase belonging to the PAK family. PAKs are critical regulators of cytoskeletal dynamics, cell motility, and survival, primarily activated by Rho-family GTPases like Cdc42 and Rac. Phosphorylation at Ser20 is a key post-translational modification associated with PAKγ activation, facilitating conformational changes that enhance its kinase activity and downstream signaling. This antibody specifically recognizes the phosphorylated serine residue at position 20. enabling researchers to study PAKγ's activation status in various biological contexts. It is widely employed in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate PAKγ's role in processes like cancer cell invasion, neuronal development, and immune response modulation. Dysregulation of PAKγ signaling has been implicated in diseases including cancer and neurological disorders, making this antibody valuable for both mechanistic studies and potential therapeutic targeting. Validation often includes testing in knock-out models or phosphatase-treated samples to confirm specificity for the phosphorylated epitope.