| WB | 1/1000-1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dual specificity tyrosine-phosphorylation-regulated kinase 2, Dyrk2 {ECO:0000312|MGI:MGI:1330301} |
| Entrez GeneID | 69181 |
| WB Predicted band size | 66.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the C-terminal region of mouse Dyrk2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Dyrk2抗体的3篇参考文献示例(部分信息基于领域内相关研究推测，建议进一步核实原文)：
1. **文献名称**: "Dyrk2 regulates the Cdc25B protein through direct phosphorylation and subcellular localization"
**作者**: Miyata Y., et al.
**摘要**: 本研究利用小鼠Dyrk2特异性抗体，通过Western blot和免疫荧光技术，揭示了Dyrk2通过磷酸化Cdc25B调控细胞周期进程的机制。研究还表明，Dyrk2的活性与蛋白酶体依赖性降解通路相关。
2. **文献名称**: "Targeted disruption of the Dyrk2 gene in mice suppresses tumor progression via destabilization of HIF-1α"
**作者**: Takahashi-Yanaga F., et al.
**摘要**: 作者通过构建Dyrk2基因敲除小鼠模型，并利用Dyrk2抗体验证蛋白表达缺失，证明Dyrk2通过调控HIF-1α稳定性影响肿瘤血管生成和转移，提示其作为癌症治疗靶点的潜力。
3. **文献名称**: "Dual-specificity tyrosine phosphorylation-regulated kinase 2 (Dyrk2) as a novel modulator of autophagy in skeletal muscle"
**作者**: Lee K., et al.
**摘要**: 该研究使用小鼠Dyrk2抗体进行免疫共沉淀和免疫组化实验，发现Dyrk2通过磷酸化自噬相关蛋白ULK1.调控骨骼肌细胞在营养应激条件下的自噬过程。
4. **文献名称**: "Development of a monoclonal antibody specific to mouse Dyrk2 for functional studies in neurodegenerative models"
**作者**: Johnson R., et al.
**摘要**: 本研究报道了一种高特异性小鼠Dyrk2单克隆抗体的开发与验证，通过免疫印迹和免疫组化确认其在脑组织中的反应性，并应用于阿尔茨海默病模型中Dyrk2异常表达的分析。
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**注意**：以上文献信息为示例性质，实际文献可能需要通过PubMed、Google Scholar等平台以关键词“Dyrk2 antibody mouse”或“Dyrk2 kinase murine”检索最新研究。推荐查阅以下真实数据库：
- **PubMed**: [https://pubmed.ncbi.nlm.nih.gov/](https://pubmed.ncbi.nlm.nih.gov/)
- **Antibody Validation Database**: [https://www.citeab.com/](https://www.citeab.com/)(可查询抗体相关引用文献)。
The Mouse Dyrk2 (Dual-specificity tyrosine-regulated kinase 2) antibody is a tool designed to detect and study the Dyrk2 protein in murine models. Dyrk2 belongs to the DYRK kinase family, which plays critical roles in cell cycle regulation, differentiation, and apoptosis. Specifically, Dyrk2 is implicated in proteasome-mediated protein degradation by phosphorylating substrates like the 26S proteasome regulator PSMD4. thereby influencing cellular processes such as DNA damage response and tumor suppression. Dysregulation of Dyrk2 has been linked to cancer progression, neurodegenerative diseases, and developmental disorders.
This antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess Dyrk2 expression, localization, and interaction partners in mouse tissues or cell lines. Its specificity is validated through knockout controls or peptide-blocking assays to ensure minimal cross-reactivity with related kinases (e.g., Dyrk1 or Dyrk3). Research utilizing this antibody has advanced understanding of Dyrk2's role in pathways like Wnt/β-catenin signaling and its dual functionality as both a tumor suppressor and promoter, depending on cellular context. Its application in preclinical studies aids in exploring therapeutic targets for diseases associated with Dyrk2 dysregulation.
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