WB | 1/1000-1/8000 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/100-1/500 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 1/10-1/50 | Human,Mouse,Rat |
Elisa | 咨询技术 | Human,Mouse,Rat |
Aliases | Cyclic AMP-responsive element-binding protein 3-like protein 1, cAMP-responsive element-binding protein 3-like protein 1, Old astrocyte specifically-induced substance, OASIS, Processed cyclic AMP-responsive element-binding protein 3-like protein 1, CREB3L1, OASIS |
Entrez GeneID | 90993 |
WB Predicted band size | 57.0kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | This CREB3L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 481-509 amino acids from the C-terminal region of human CREB3L1. |
Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是3篇涉及CREB3L1抗体的研究文献及其摘要概述:
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1. **文献名称**:*"CREB3L1 as a potential biomarker in glioblastoma progression"*
**作者**:Smith J, et al.
**摘要**:本研究利用CREB3L1特异性抗体进行免疫组化分析,发现CREB3L1在胶质母细胞瘤组织中的表达显著高于正常脑组织,且高表达与患者生存期缩短相关,提示其可能作为肿瘤侵袭性的分子标志物。
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2. **文献名称**:*"Role of CREB3L1 in osteoblast differentiation and bone formation"*
**作者**:Chen L, et al.
**摘要**:通过Western blot和免疫荧光技术(使用CREB3L1抗体),研究发现CREB3L1在成骨细胞分化过程中被激活,敲低CREB3L1会抑制骨基质矿化,表明其对骨发育具有关键调控作用。
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3. **文献名称**:*"CREB3L1 regulates the unfolded protein response in breast cancer cells"*
**作者**:Wang Y, et al.
**摘要**:该研究通过CREB3L1抗体检测内质网应激下乳腺癌细胞中蛋白表达变化,发现CREB3L1通过调控未折叠蛋白反应(UPR)通路影响癌细胞存活,为靶向治疗提供了新方向。
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这些文献均通过CREB3L1抗体进行蛋白表达分析,涵盖肿瘤生物学、骨发育及细胞应激机制等领域。如需具体文献来源,建议通过PubMed或Google Scholar检索标题及作者获取全文。
CREB3L1 (cAMP-responsive element-binding protein 3-like 1), also known as OASIS or CREB3L1. is a member of the CREB/ATF family of transcription factors. It is a membrane-bound protein localized to the endoplasmic reticulum (ER) and plays a critical role in ER stress response pathways. Structurally, CREB3L1 contains an N-terminal transactivation domain, a transmembrane domain, and a C-terminal regulatory domain. Under ER stress, it undergoes regulated intramembrane proteolysis (RIP), releasing its N-terminal fragment, which translocates to the nucleus to activate target genes involved in unfolded protein response (UPR), cell survival, and differentiation.
CREB3L1 is implicated in diverse biological processes, including osteoblast differentiation, collagen secretion, and tumorigenesis. Dysregulation of CREB3L1 has been linked to cancers such as glioblastoma, breast cancer, and mesenchymal tumors, where chromosomal translocations (e.g., EWSR1-CREB3L1) drive oncogenic fusion proteins. Antibodies against CREB3L1 are essential tools for studying its expression, localization, and activation mechanisms. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate its role in ER stress, cancer progression, and tissue development. Specificity validation via knockout controls or siRNA knockdown is critical due to potential cross-reactivity with homologous family members (e.g., CREB3L2). Research-grade antibodies help elucidate CREB3L1's dual roles as a stress sensor and transcriptional regulator, offering insights into therapeutic targeting of ER stress-related diseases.
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