Rabbit Polyclonal SLC16A11(N-term) Antibody

The SLC16A11 (N-term) antibody is a tool designed to detect the N-terminal region of the solute carrier family 16 member 11 (SLC16A11), a transmembrane protein belonging to the monocarboxylate transporter (MCT) family. SLC16A11 is implicated in lipid metabolism and type 2 diabetes (T2D) pathogenesis. Genome-wide association studies (GWAS) identified SLC16A11 as a risk locus for T2D, particularly in Latin American populations. The protein localizes to intracellular organelles (e.g., endoplasmic reticulum) and may regulate hepatic lipid handling by transporting metabolites like pyruvate or fatty acids. Its dysfunction is linked to altered triglyceride levels and insulin resistance. The N-terminal antibody enables research into SLC16A11’s expression, localization, and function. It is commonly used in techniques like Western blotting, immunohistochemistry, or immunofluorescence to study tissue-specific distribution (e.g., liver, kidney, thyroid) or disease-related expression changes. The antibody’s specificity for the N-terminus ensures recognition of full-length protein variants, avoiding cross-reactivity with truncated forms. Understanding SLC16A11’s role through this antibody provides insights into metabolic disorders and potential therapeutic targets. Recent studies also explore its interaction with other proteins (e.g., SLC16A13) and its impact on cellular energy balance, underscoring its relevance in metabolic research.