| WB | 1/1000 | zebrafish |
| IF | 咨询技术 | zebrafish |
| IHC | 咨询技术 | zebrafish |
| ICC | 技术咨询 | zebrafish |
| FCM | 咨询技术 | zebrafish |
| Elisa | 咨询技术 | zebrafish |
| Aliases | Sterol regulatory element-binding protein 2, SREBP-2, Sterol regulatory element-binding transcription factor 2, Processed sterol regulatory element-binding protein 2, srebf2 {ECO:0000250|UniProtKB:Q12772} |
| Entrez GeneID | 100037309 |
| WB Predicted band size | 120.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | zebrafish |
| Immunogen | This (DANRE) srebf2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 441-473 amino acids of DANRE srebf2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于斑马鱼(Danio rerio)**SREBF2抗体**的参考文献示例，内容为虚构归纳，仅供参考：
---
1. **文献名称**：*SREBP-2 regulates lipid metabolism in zebrafish liver development*
**作者**：Zhang L, et al.
**摘要**：本研究利用斑马鱼模型，通过特异性SREBF2抗体进行Western blot和免疫组化分析，揭示了SREBF2在肝脏发育中对胆固醇合成的调控作用，并验证了抗体在胚胎及成体组织中的特异性。
2. **文献名称**：*Antibody validation for SREBF2 in Danio rerio: Applications in lipid metabolism studies*
**作者**：Chen R, et al.
**摘要**：文章系统验证了斑马鱼SREBF2抗体的特异性，通过基因敲除实验和免疫荧光染色证明该抗体可准确识别内源性SREBF2蛋白，并用于高脂饮食模型中脂质代谢异常的机制探索。
3. **文献名称**：*SREBF2-mediated lipogenesis in zebrafish adipogenesis*
**作者**：Kimura S, et al.
**摘要**：研究使用SREBF2抗体分析斑马鱼脂肪组织分化过程，发现SREBF2通过激活脂肪酸合成相关基因表达促进脂质积累，抗体在蛋白定位及表达量检测中表现出高灵敏度。
4. **文献名称**：*Role of SREBF2 in zebrafish neuronal cholesterol homeostasis*
**作者**：Wang Y, et al.
**摘要**：通过免疫沉淀和SREBF2抗体标记，研究证实SREBF2在斑马鱼神经系统胆固醇稳态中起关键作用，抗体特异性通过siRNA敲降实验验证，为神经发育疾病研究提供工具。
---
注：以上文献为示例性质，实际引用时需以真实发表的论文为准。建议通过PubMed或Web of Science以关键词“SREBF2 antibody Danio rerio”检索最新研究。
The DANRE (Danio rerio) SREBF2 antibody is designed to detect Sterol Regulatory Element-Binding Transcription Factor 2 (SREBF2) in zebrafish models. SREBF2. a member of the SREBP family, is a key regulator of lipid metabolism, primarily controlling cholesterol biosynthesis and uptake by binding to sterol regulatory elements in target gene promoters. Unlike SREBF1. which focuses on fatty acid synthesis, SREBF2 is crucial for maintaining cellular cholesterol homeostasis.
In zebrafish research, SREBF2 is studied for its conserved role in lipid regulation and its implications in metabolic diseases, atherosclerosis, and developmental processes. The DANRE SREBF2 antibody enables localization and quantification of SREBF2 protein expression in tissues like the liver, brain, and gonads, providing insights into its spatial and temporal activity during embryogenesis or under dietary/ pharmacological perturbations.
This antibody is widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Its application supports investigations into lipid metabolism disorders, cardiovascular disease mechanisms, and neurodevelopmental pathways in a vertebrate model renowned for genetic tractability and translational relevance. Validation via knockout controls or peptide blocking ensures specificity, making it a critical tool for developmental biology and metabolic research.
×
