| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein Hox-A1, Early retinoic acid 1, Homeobox protein Hox-16, Homeoboxless protein ERA-1-399, Homeotic protein ERA-1-993, Hoxa1, Era-1, Hox-16, Hoxa-1 |
| WB Predicted band size | 36.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Mouse Hoxa1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-219 amino acids from the Central region of mouse Hoxa1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Mouse Hoxa1抗体的3篇参考文献(示例为模拟内容，实际文献需根据数据库查询)：
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1. **文献名称**: *Hoxa1 is required for embryonic hindbrain development and cranial neural crest specification*
**作者**: Chanda, B., et al.
**摘要**: 本研究利用Hoxa1特异性抗体进行免疫组化分析，揭示了Hoxa1在小鼠胚胎后脑发育中的关键作用，证明其缺失导致颅神经嵴细胞迁移异常。抗体验证通过Western blot和敲除模型确认特异性。
2. **文献名称**: *Functional analysis of Hoxa1 in murine embryogenesis using targeted mutation*
**作者**: Carpenter, E.M., Capecchi, M.R.
**摘要**: 通过基因靶向技术构建Hoxa1突变小鼠，并采用Hoxa1抗体进行蛋白表达检测，发现其在前脑和中脑区域的表达模式异常，揭示了Hoxa1在胚胎前后轴模式化中的调控机制。
3. **文献名称**: *Regulation of Hoxa1 expression by retinoic acid signaling in early mouse embryos*
**作者**: Gavalas, A., Krumlauf, R.
**摘要**: 利用Hoxa1抗体进行免疫荧光染色，研究视黄酸信号对小鼠胚胎Hoxa1表达的调控，发现其在前体神经管中的动态表达依赖于特定信号通路，抗体特异性经siRNA敲低实验验证。
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(注：以上文献信息为示例，实际引用请通过PubMed或Google Scholar搜索关键词“Hoxa1 antibody mouse”获取真实文献。)
The mouse Hoxa1 antibody is a specialized tool used to detect and study the Hoxa1 protein, a member of the Hox gene family critical in regulating embryonic development and body patterning. Hoxa1. part of the HoxA cluster on chromosome 6. encodes a transcription factor that governs anterior-posterior axis formation, particularly in the hindbrain and cranial neural crest cells. It plays a pivotal role in early embryogenesis, influencing segmentation, neural tube development, and craniofacial morphogenesis. Researchers employ this antibody to investigate Hoxa1's expression dynamics, localization, and function in developmental processes.
The antibody is typically raised in hosts like rabbits or mice using immunogenic peptides specific to the mouse Hoxa1 protein. It is validated for applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), enabling precise detection in tissue sections or cell lysates. Studies using this antibody have elucidated Hoxa1's role in neurogenesis, its interaction with signaling pathways like retinoic acid, and its association with congenital disorders, including hearing loss or craniofacial anomalies in knockout models.
Quality control measures, such as knockout validation or peptide blocking assays, ensure specificity. Its utility spans developmental biology, genetic research, and disease modeling, offering insights into Hox gene regulatory networks and congenital defect mechanisms. Commercial suppliers often provide detailed validation data to support experimental reproducibility.
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