| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | G protein-coupled receptor kinase 7, G protein-coupled receptor kinase GRK7, GRK7, GPRK7 |
| Entrez GeneID | 131890 |
| WB Predicted band size | 62.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GRK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 508-538 amino acids from the C-terminal region of human GRK7. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与GRK7抗体相关的文献摘要示例(注：文献信息为模拟示例，非真实存在)：
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1. **文献名称**: "Characterization of a Novel Monoclonal Antibody for GRK7 in Photoreceptor Signaling"
**作者**: Chen L, et al.
**摘要**: 本研究开发了一种特异性识别GRK7的单克隆抗体，验证了其在哺乳动物视网膜组织中的表达定位，证实GRK7在视杆细胞光信号转导中通过磷酸化视紫红质调控脱敏过程。
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2. **文献名称**: "GRK7 Knockout Mice Reveal Its Role in Retinal Degeneration via Antibody-Based Profiling"
**作者**: Martinez R, et al.
**摘要**: 通过GRK7抗体免疫组化分析发现，GRK7缺失小鼠视网膜中光受体细胞凋亡加剧，提示GRK7可能通过调控GPCR信号通路参与视网膜退行性疾病的病理过程。
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3. **文献名称**: "Development of a Phospho-Specific GRK7 Antibody for Studying Cone Photoreceptor Adaptation"
**作者**: Kim S, et al.
**摘要**: 该文献报道了一种磷酸化特异性GRK7抗体的制备方法，并证明其在研究视锥细胞光适应过程中GRK7活性动态变化的实验应用，揭示了光照强度与GRK7自磷酸化的相关性。
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注：实际文献需通过PubMed、Google Scholar等平台以“GRK7 antibody”为关键词检索，建议参考近5年《Journal of Biological Chemistry》《Investigative Ophthalmology & Visual Science》等期刊。
GRK7 (G protein-coupled receptor kinase 7) is a member of the GRK family, which regulates the activity of G protein-coupled receptors (GPCRs) through phosphorylation, leading to receptor desensitization and downstream signaling modulation. Specifically, GRK7 is predominantly expressed in retinal photoreceptor cells, where it plays a critical role in phototransduction. It primarily targets rhodopsin and cone opsins in vertebrates, facilitating the termination of light-induced signaling by phosphorylating activated visual pigments. This process is essential for maintaining photoreceptor sensitivity and adapting to varying light conditions. Dysregulation of GRK7 has been implicated in visual disorders, including congenital stationary night blindness and retinal degeneration.
Antibodies against GRK7 are vital tools for studying its expression, localization, and function in retinal tissues. They enable researchers to investigate GRK7's role in photoreceptor physiology, its interaction with visual pigments, and its contribution to retinal pathologies. Such antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels, tissue distribution, and cellular dynamics. Due to GRK7's high homology with other GRK isoforms (e.g., GRK1), antibody specificity is crucial to avoid cross-reactivity. Research using GRK7 antibodies has advanced understanding of visual signal transduction mechanisms and potential therapeutic targets for vision-related diseases.
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