| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | HLA-DQB1; HLA-DQB; HLA class II histocompatibility antigen; DQ beta 1 chain; MHC class II antigen DQB1; HLA-DQB2; HLA-DXB; HLA class II histocompatibility antigen; DQ beta 2 chainHLA class II histocompatibility antigen; DX beta chain; MHC class II antigen DQB2 |
| Entrez GeneID | 3119/3120 |
| WB Predicted band size | Calculated MW: 30 kDa; Observed MW: 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human HLA-DQB1/HLA-DQB2. AA range:131-180 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于HLA-DQB1/2抗体的3篇代表性文献的简要信息(文献标题与作者为虚构示例，仅供格式参考)：
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1. **文献名称**：*HLA-DQ Antibodies as Biomarkers in Celiac Disease*
**作者**：Smith A, et al.
**摘要**：研究分析了HLA-DQB1*02抗体在乳糜泻患者中的表达，发现其与组织转谷氨酰胺酶抗体(tTG-IgA)的共现率显著，提示HLA-DQ抗体可能作为乳糜泻的辅助诊断标志物。
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2. **文献名称**：*Role of HLA-DQB1 Antibodies in Pancreatic Islet Autoimmunity*
**作者**：Johnson R, et al.
**摘要**：探讨HLA-DQB1等位基因相关抗体在1型糖尿病中的致病机制，发现特定HLA-DQ表位抗体可通过激活T细胞促进胰岛β细胞破坏，为免疫干预提供靶点。
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3. **文献名称**：*Impact of HLA-DQ Donor-Specific Antibodies on Kidney Transplant Outcomes*
**作者**：Lee C, et al.
**摘要**：回顾性研究显示，受体中预存的HLA-DQB1/2供体特异性抗体(DSA)与移植后急性排斥反应风险增加相关，强调移植前抗体筛查的重要性。
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**备注**：HLA-DQB2基因在人群中的多态性较低，相关抗体研究较少，现有文献多集中于HLA-DQB1.实际研究中，建议通过PubMed或专业数据库(如NCBI、EMBASE)以关键词“HLA-DQ antibodies”“HLA-DQB1 autoimmunity”等检索最新文献。
HLA-DQB1 and HLA-DQB2 are genes within the human leukocyte antigen (HLA) complex on chromosome 6. encoding β-chain subunits of HLA-DQ heterodimers, which are critical for antigen presentation in immune responses. HLA-DQB1 pairs with HLA-DQA1 to form the functional HLA-DQ molecule, playing a central role in recognizing foreign peptides and triggering adaptive immunity. In contrast, HLA-DQB2. a paralog of DQB1. pairs with HLA-DQA2. but its protein product is less expressed and poorly understood, with limited evidence for stable cell-surface expression or immunological function.
Antibodies targeting HLA-DQB1/2 are clinically significant in transplant medicine and autoimmune diseases. HLA-DQB1 antibodies are commonly implicated in organ transplant rejection, particularly in kidney and hematopoietic stem cell transplantation, due to their role in allorecognition. They are also associated with autoimmune conditions like celiac disease (linked to DQ2/DQ8 variants) and type 1 diabetes. HLA-DQB2 antibodies are less frequently reported, likely due to lower immunogenicity, though their clinical impact remains understudied.
These antibodies often arise from sensitization events (e.g., pregnancy, transfusions, or prior transplants). Detection via solid-phase assays (e.g., single-antigen bead technology) aids in assessing transplant compatibility and managing alloimmune risks. Research continues to clarify DQB2’s immunogenicity and its potential role in graft failure or autoimmunity.
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