| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | hPOMp100; POMP100; PPP1R140; PSF; Sfpq; Splicing factor;;SFPQ |
| WB Predicted band size | Calculated MW: 76 kDa ; Observed MW: 100 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human SFPQ |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
+ +
以下是3篇关于KLF13抗体的虚构参考文献示例(仅供格式参考)：
---
1. **标题**: *KLF13 regulates cardiac hypertrophy through transcriptional repression of pro-hypertrophic genes*
**作者**: Smith A, et al.
**摘要**: 研究利用KLF13特异性抗体在小鼠心肌细胞中发现KLF13通过抑制NFAT信号通路减轻病理性心肌肥厚，Western blot和ChIP实验证实其直接结合靶基因启动子。
---
2. **标题**: *KLF13 suppresses colorectal cancer progression by modulating Wnt/β-catenin signaling*
**作者**: Chen L, et al.
**摘要**: 通过免疫组化分析显示，KLF13在结直肠癌组织中低表达，其抗体检测证实KLF13过表达可抑制β-catenin核转位，延缓肿瘤细胞增殖和转移。
---
3. **标题**: *KLF13 antibody-based profiling reveals its role in T-cell differentiation and autoimmunity*
**作者**: Gupta R, et al.
**摘要**: 研究使用KLF13抗体流式分选T细胞亚群，发现KLF13缺失导致Th17细胞分化异常，提示其在自身免疫疾病(如多发性硬化)中的调控作用。
---
注：以上为模拟内容，实际文献需通过PubMed/Google Scholar检索关键词"KLF13 antibody"或"KLF13 function"获取。
**Background of KLF13 Antibody**
The Krüppel-like factor 13 (KLF13), also known as RFLAT-1 or BTF3. is a transcription factor belonging to the Krüppel-like family, characterized by zinc finger DNA-binding domains. KLF13 plays critical roles in regulating gene expression involved in cardiovascular development, immune response, and cellular differentiation. It is particularly notable for its involvement in T-cell activation, cardiac remodeling, and adipocyte metabolism.
KLF13 antibodies are essential tools for detecting and quantifying KLF13 protein levels in experimental settings, enabling researchers to study its expression patterns, subcellular localization, and interactions with target genes. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP).
Research utilizing KLF13 antibodies has linked the protein to various pathological conditions, including heart failure, diabetes, and cancer. For instance, KLF13 dysregulation has been implicated in cardiac hypertrophy and fibrosis, while its role in lipid metabolism highlights its potential relevance in metabolic disorders. Antibody specificity is validated through knockout controls or siRNA-mediated silencing to ensure accurate detection.
As a relatively understudied member of the KLF family, KLF13 continues to gain attention for its diverse regulatory functions, making specific and reliable antibodies crucial for advancing mechanistic insights into its biological and pathological roles. Commercial KLF13 antibodies are typically raised in rabbits or mice, targeting epitopes within conserved regions of the protein.
×
