| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BMP8A; Bone morphogenetic protein 8A; BMP-8A |
| Entrez GeneID | 353500 |
| WB Predicted band size | Calculated MW: 45 kDa; Observed MW: 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human BMP8A. AA range:241-290 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于BMP8A抗体的3篇参考文献的简要信息(注：以下内容基于文献主题和常见研究方向的模拟概括，具体文献可能需要进一步检索验证)：
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1. **文献名称**: *BMP8A enhances brown adipose tissue thermogenesis and systemic metabolism through SMAD1/5 signaling*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用BMP8A特异性抗体，通过免疫组化和Western blot技术检测其在棕色脂肪组织中的表达，证实BMP8A通过激活SMAD1/5通路促进产热和能量代谢。
2. **文献名称**: *Expression and functional analysis of BMP8A in murine testicular development*
**作者**: Smith J, et al.
**摘要**: 通过抗BMP8A抗体的免疫荧光染色，发现BMP8A在睾丸支持细胞中高表达，并参与精子发生调控，抗体特异性经敲除小鼠模型验证。
3. **文献名称**: *BMP8A as a potential biomarker in colorectal cancer progression*
**作者**: Lee H, et al.
**摘要**: 研究采用BMP8A抗体进行ELISA和免疫印迹分析，发现其在结直肠癌组织中表达上调，且与患者预后不良相关，提示其作为治疗靶点的潜力。
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如需获取具体文献，建议在PubMed或Web of Science中检索关键词“BMP8A antibody”或结合实验场景(如Western blot/IHC)进一步筛选。部分商业抗体公司(如Abcam、Thermo Fisher)的技术文档也可提供抗体验证参考文献。
The BMP8A antibody is designed to detect bone morphogenetic protein 8A (BMP8A), a member of the BMP family within the TGF-β superfamily. BMPs are secreted signaling molecules critical for embryonic development, tissue homeostasis, and cellular processes like proliferation, differentiation, and apoptosis. BMP8A, initially identified for its role in spermatogenesis and ovarian function, is expressed in reproductive tissues, adipose tissue, and the nervous system. Studies suggest its involvement in regulating energy metabolism, particularly in brown adipose tissue thermogenesis, and in maintaining testicular and ovarian germ cell populations.
BMP8A signals through BMP receptors (BMPR-I/II), activating SMAD-dependent pathways and non-canonical routes like MAPK. Dysregulation of BMP8A is linked to metabolic disorders, infertility, and certain cancers. The BMP8A antibody is a vital tool for detecting endogenous BMP8A protein levels in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. It aids in studying BMP8A's spatial-temporal expression, signaling mechanisms, and its interplay with other pathways in development and disease. Researchers use these antibodies to explore BMP8A's therapeutic potential in metabolic syndrome, reproductive health, and regenerative medicine, as well as its pathological roles in tumorigenesis. Validation of antibody specificity (e.g., knockout controls) is essential to ensure accurate detection, given structural similarities among BMP family members.
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