| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL-28; IL28A; IFNL2; ZCYTO20; Interleukin-28A; IL-28A; Cytokine Zcyto20; Interferon lambda-2; IFN-lambda-2 |
| Entrez GeneID | 282616 |
| WB Predicted band size | Calculated MW: 22 kDa; Observed MW: 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human IL28A. AA range:131-180 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于IL-28抗体的3篇参考文献，涵盖其治疗应用、机制研究及检测开发方向：
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1. **文献名称**：*"A monoclonal antibody against human IL-28A/IL-28B neutralizes biological activity in vitro"*
**作者**：Menno de Jong, et al.
**摘要**：该研究开发了一种靶向IL-28A/IL-28B的单克隆抗体，证明其能在体外有效中和IL-28的活性，为研究III型干扰素的功能及潜在治疗应用提供了工具。
2. **文献名称**：*"IL-28 receptor signaling regulates antiviral immunity through natural killer cell activation"*
**作者**：Paul Sheppard, et al.
**摘要**：通过使用IL-28中和抗体，本文揭示了IL-28受体信号通路在激活自然杀伤(NK)细胞抗病毒免疫中的关键作用，为免疫调节治疗策略提供依据。
3. **文献名称**：*"The role of IL-28B antibody in predicting hepatitis C treatment response"*
**作者**：Yasuhito Tanaka, et al.
**摘要**：研究探讨了IL-28B多态性与抗体检测在丙肝患者中的临床意义，发现特定IL-28B抗体水平与干扰素治疗应答率显著相关，助力个体化治疗决策。
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以上文献示例基于IL-28抗体的功能研究和应用场景，具体细节需参考原文以获取完整信息。
Interleukin-28 (IL-28), a member of the type III interferon (IFN-λ) family, includes two subtypes: IL-28A (IFN-λ2) and IL-28B (IFN-λ3). These cytokines bind to a heterodimeric receptor complex (IL-10Rβ and IFN-λR1) to activate JAK-STAT signaling, inducing antiviral and immunomodulatory responses. IL-28 antibodies are tools developed to detect, neutralize, or modulate IL-28 activity in research and therapeutic contexts. Neutralizing antibodies, for instance, block IL-28/receptor interactions, helping elucidate its role in viral defense, autoimmune diseases, and cancer.
IL-28 antibodies have been pivotal in studying hepatitis C virus (HCV) outcomes, as IL-28B polymorphisms correlate with treatment response and spontaneous viral clearance. They are also used to explore IL-28's dual role in cancer—promoting antitumor immunity in some contexts while supporting immunosuppressive microenvironments in others. Additionally, IL-28 antibodies aid in diagnostic assays (e.g., ELISA) to quantify cytokine levels in clinical samples.
Therapeutic applications remain experimental, with studies investigating antibody-based strategies to enhance antiviral therapies or mitigate inflammatory conditions. Challenges include optimizing antibody specificity and addressing tissue-specific IL-28 responses. Overall, IL-28 antibodies are critical for dissecting its biological functions and advancing translational research.
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