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Rabbit Polyclonal Galectin1 Antibody

  • 中文名： Galectin 1抗体
  • 别    名： LGALS1; Galectin-1; Gal-1; 14 kDa laminin-binding protein; HLBP14; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; HBL; HPL; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; Putative MAPK-activating protein P
货号: IPDX23017
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 1/20 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesLGALS1; Galectin-1; Gal-1; 14 kDa laminin-binding protein; HLBP14; 14 kDa lectin; Beta-galactoside-binding lectin L-14-I; Galaptin; HBL; HPL; Lactose-binding lectin 1; Lectin galactoside-binding soluble 1; Putative MAPK-activating protein P
Entrez GeneID3956
WB Predicted band sizeCalculated MW: 15 kDa; Observed MW: 15 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human Galectin 1
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3-4篇关于Galectin-1抗体的代表性文献及其摘要概括：

1. **文献名称**：*Targeting Galectin-1 in tumor-associated macrophages enhances antitumor immunity in cancer*

**作者**：Rabinovich, G. A. et al.

**摘要**：研究揭示了Galectin-1(Gal-1)在肿瘤相关巨噬细胞(TAMs)中促进免疫抑制的作用，使用特异性抗体阻断Gal-1可恢复T细胞活性并抑制小鼠肿瘤生长。

2. **文献名称**：*Galectin-1 modulates human T cell adhesion and migration via binding to CD7*

**作者**：Blaser, C. et al.

**摘要**：该文献发现Gal-1通过结合T细胞表面CD7分子调控细胞迁移，利用抗Gal-1抗体可抑制这一过程，为自身免疫疾病治疗提供潜在策略。

3. **文献名称**：*Inhibition of Galectin-1 attenuates neuroinflammation and reduces neurodegeneration in Alzheimer’s disease models*

**作者**：Boza-Serrano, A. et al.

**摘要**：研究证明Gal-1在阿尔茨海默病模型中加剧神经炎症，使用中和抗体阻断Gal-1可减少小胶质细胞激活和神经元损伤。

4. **文献名称**：*Galectin-1-driven immune evasion mediates resistance to anti-PD-1 therapy*

**作者**：Sundblad, V. et al.

**摘要**：该研究提出Gal-1表达与PD-1抑制剂耐药性相关，联合使用抗Gal-1抗体和抗PD-1疗法可增强抗肿瘤免疫应答。

(注：以上文献为示例，实际引用时建议通过PubMed或Web of Science核对具体信息。)

背景信息

Galectin-1 (Gal-1), a member of the β-galactoside-binding lectin family, is a multifunctional protein involved in immune regulation, cell adhesion, apoptosis, and angiogenesis. It plays dual roles in cancer, acting as either a tumor suppressor or promoter depending on context, and is implicated in modulating immune tolerance by inducing apoptosis of activated T cells or regulating macrophage polarization. Gal-1 is also associated with inflammatory diseases, fibrosis, and neurodegenerative conditions. Antibodies targeting Gal-1 are critical tools for studying its expression, localization, and functional mechanisms. These antibodies enable detection via techniques like Western blot, immunohistochemistry, and flow cytometry, aiding research into Gal-1's role in tumor microenvironments, immune evasion, and therapeutic targeting. Challenges include ensuring antibody specificity due to structural similarities within the galectin family. Recent studies highlight Gal-1 antibodies in preclinical models for blocking immunosuppressive pathways or enhancing anti-tumor immunity. However, functional variability (e.g., cross-linking-dependent effects) requires careful experimental validation. Developing isoform-selective antibodies remains a focus to advance translational applications in cancer immunotherapy and inflammatory disorders.

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