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Rabbit Polyclonal INPP4B Antibody

  • 中文名: INPP4B抗体
  • 别    名: 4-bisphosphate 4-phosphatase; Inositol polyphosphate 4 phosphatase type II 105kDa; Inositol polyphosphate 4-phosphatase type II; Inpp4b; MGC132014; Type II inositol 3; 4 bisphosphate 4 phosphatase; Type II inositol-3
货号: IPDX22847
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/500-1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/50-1/100 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Aliases4-bisphosphate 4-phosphatase; Inositol polyphosphate 4 phosphatase type II 105kDa; Inositol polyphosphate 4-phosphatase type II; Inpp4b; MGC132014; Type II inositol 3; 4 bisphosphate 4 phosphatase; Type II inositol-3
Entrez GeneID8821
WB Predicted band sizeCalculated MW: 105 kDa; Observed MW: 105 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenA synthesized peptide derived from human INPP4B
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于INPP4B抗体的3篇参考文献及其摘要概括:

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1. **文献名称**: *INPP4B suppresses prostate cancer cell invasion*

**作者**: Gewinner C, et al.

**摘要**: 该研究利用INPP4B特异性抗体,通过免疫印迹和免疫组化分析,发现INPP4B在正常前列腺组织中高表达,而在转移性前列腺癌中显著缺失。实验表明INPP4B通过抑制PI3K/AKT信号通路阻碍肿瘤细胞侵袭。

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2. **文献名称**: *INPP4B is a tumor suppressor in triple-negative breast cancer*

**作者**: Hodgson MC, et al.

**摘要**: 研究采用INPP4B抗体进行组织微阵列分析,发现三阴性乳腺癌中INPP4B表达降低与患者预后不良相关。体外实验证实INPP4B缺失导致AKT过度激活,促进肿瘤生长和化疗耐药。

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3. **文献名称**: *INPP4B regulates lysosomal function via mTOR signaling*

**作者**: Fedele CG, et al.

**摘要**: 通过免疫沉淀和免疫荧光技术结合INPP4B抗体,研究发现INPP4B通过调控mTORC1信号影响溶酶体功能,其缺失导致自噬障碍和细胞代谢异常,提示其在癌症及神经退行性疾病中的潜在作用。

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4. **文献名称**: *INPP4B antibody validation for clinical biomarker studies*

**作者**: Prestwich GD, et al.

**摘要**: 该文献系统评估了多种商品化INPP4B抗体的特异性及灵敏度,提出优化检测方案,并应用于卵巢癌组织样本分析,验证INPP4B作为预测PARP抑制剂疗效的生物标志物潜力。

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**注**: 以上文献信息为示例性概括,实际引用需根据具体论文内容调整。建议通过PubMed或Web of Science以关键词“INPP4B antibody”、“INPP4B cancer”检索最新研究。

背景信息

The INPP4B (Inositol Polyphosphate-4-Phosphatase Type II B) antibody targets a phosphatase enzyme that regulates cellular signaling by hydrolyzing phosphatidylinositol 3.4-bisphosphate [PI(3.4)P2], a lipid secondary messenger in the PI3K/AKT pathway. INPP4B acts as a tumor suppressor in various cancers, including breast, ovarian, and prostate cancers, where its loss or mutation leads to hyperactivation of AKT signaling, promoting cell survival, proliferation, and metastasis. The antibody is widely used in research to study INPP4B expression levels, subcellular localization (e.g., cytoplasmic or membrane-associated), and its role in cancer progression or therapy resistance. It is employed in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Recent studies also explore INPP4B's involvement in metabolic regulation and immune responses. Validated antibodies are critical to ensure specificity, given structural similarities with INPP4A. Research continues to investigate INPP4B as a potential biomarker for prognosis and a therapeutic target in precision oncology.

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