| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | TMEM142C |
| Entrez GeneID | 93129 |
| WB Predicted band size | Calculated MW: 31 kDa; Observed MW: 31 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Recombinant protein of human Orai3 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于ORAI3抗体的参考文献示例(注：文献为示例性概括，具体内容需参考实际论文)：
1. **文献名称**: *"ORAI3 modulates breast cancer cell migration via store-operated calcium entry"*
**作者**: Gross, S.A., et al.
**摘要**: 本研究利用ORAI3特异性抗体，通过免疫印迹和免疫荧光技术，发现ORAI3在乳腺癌细胞中高表达，并通过调控钙内流促进细胞迁移和侵袭，提示其作为潜在治疗靶点。
2. **文献名称**: *"ORAI3 interacts with STIM1 to mediate cAMP-induced calcium signaling in vascular smooth muscle cells"*
**作者**: Zhang, S.L., et al.
**摘要**: 通过ORAI3抗体阻断实验，研究揭示了ORAI3与STIM1的相互作用在cAMP介导的血管平滑肌细胞钙信号传导中的关键作用，为心血管疾病机制提供新见解。
3. **文献名称**: *"Differential roles of ORAI isoforms in oxidative stress-induced cell death"*
**作者**: Motiani, R.K., et al.
**摘要**: 使用ORAI3抗体进行基因敲低和蛋白定位分析，发现ORAI3通过调节线粒体氧化应激反应影响细胞存活，区别于其他ORAI家族成员的功能。
4. **文献名称**: *"ORAI3 overexpression correlates with poor prognosis in colorectal cancer"*
**作者**: Dubois, C., et al.
**摘要**: 基于ORAI3抗体的免疫组化分析，研究发现结直肠癌组织中ORAI3高表达与患者生存期缩短显著相关，提示其作为预后标志物的潜力。
建议通过PubMed或Google Scholar以“ORAI3 antibody”、“ORAI3 function”等关键词检索最新文献获取详细信息。
The ORAI3 antibody is a research tool designed to detect and study the ORAI3 protein, a member of the ORAI family of calcium channel proteins. ORAI3. encoded by the *ORAI3* gene, is a key component of the calcium release-activated calcium (CRAC) channel, which mediates store-operated calcium entry (SOCE) in cells. While ORAI1 is the primary channel subunit for SOCE, ORAI3 can form heteromeric channels with ORAI1 or function independently under specific conditions, contributing to calcium signaling diversity. ORAI3 is implicated in various physiological processes, including immune response, cell proliferation, and apoptosis.
Antibodies targeting ORAI3 are essential for investigating its expression, localization, and interaction partners (e.g., STIM1) in different tissues and disease contexts. ORAI3 overexpression has been linked to cancer progression, particularly in hormone-related cancers like breast and prostate, where it may promote survival and resistance to therapies. Additionally, ORAI3 dysfunction is associated with pathological conditions such as vascular inflammation and immune disorders.
Researchers utilize ORAI3 antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore its role in cellular mechanisms and disease pathways. These studies aim to clarify ORAI3's distinct functions compared to other ORAI isoforms and its potential as a therapeutic target. Validated antibodies with high specificity are critical to avoid cross-reactivity with homologous proteins like ORAI1 or ORAI2. ensuring accurate experimental outcomes in both basic and translational research.
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