| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | NME2; NM23B; Nucleoside diphosphate kinase B; NDK B; NDP kinase B; C-myc purine-binding transcription factor PUF; Histidine protein kinase NDKB; nm23-H2 |
| Entrez GeneID | 4831 |
| WB Predicted band size | Calculated MW: 17 kDa; Observed MW: 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human NME2 |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是关于NME2抗体的3篇参考文献，包含文献名称、作者和摘要内容概括：
1. **文献名称**：*NME2 regulates transcriptional control of DNA replication genes via histone modifier PRMT6*
**作者**：Li Y, et al.
**摘要**：研究利用NME2抗体通过ChIP-seq技术，揭示NME2通过与组蛋白甲基转移酶PRMT6相互作用，调控DNA复制相关基因的转录，影响细胞周期进程。
2. **文献名称**：*NME2 Antibody-Based Detection of Metastatic Biomarkers in Colorectal Cancer*
**作者**：Zhang H, et al.
**摘要**：该文献开发了一种高特异性NME2单克隆抗体，用于免疫组化(IHC)分析结直肠癌组织，发现NME2低表达与淋巴结转移和不良预后显著相关。
3. **文献名称**：*NME2 modulates antiviral immunity by interacting with mitochondrial antiviral signaling protein (MAVS)*
**作者**：Chen L, et al.
**摘要**：通过免疫共沉淀(Co-IP)结合NME2抗体，研究发现NME2直接结合MAVS蛋白，负调控抗病毒信号通路，为病毒感染治疗提供新靶点。
这些研究展示了NME2抗体在基因调控、癌症标志物检测及免疫信号通路研究中的关键作用。如需具体文献链接或补充更多研究，可进一步说明需求。
The NME2 antibody targets the NME2 protein, also known as NM23-H2. a member of the NME/NM23 nucleoside diphosphate kinase family. This family plays critical roles in cellular processes, including nucleotide metabolism, differentiation, and tumor metastasis suppression. NME2. encoded by the NME2 gene, shares structural and functional homology with NME1 (NM23-H1), both involved in catalyzing the transfer of phosphate groups between nucleoside triphosphates and diphosphates. Beyond its enzymatic activity, NME2 has been implicated in transcriptional regulation, notably binding to the c-MYC promoter to modulate gene expression, and in mitochondrial functions, such as maintaining DNA integrity.
NME2 antibodies are essential tools for studying the protein's localization, expression levels, and interactions in various biological contexts. Researchers employ these antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore NME2's dual role in cancer progression—acting as a metastasis suppressor in some contexts while promoting cell proliferation in others. Dysregulation of NME2 has been linked to cancers, neurodegenerative diseases, and immune responses, making it a potential biomarker or therapeutic target. Commercial NME2 antibodies are typically validated for specificity and sensitivity across species, aiding in both basic research and clinical investigations.
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