| WB | 1/500-1/1000 | Human,Mouse,Rat |
| IF | 1/20 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | LOQS; Prbp; tarbp2; TRBP; TRBP1; TRBP2 |
| Entrez GeneID | 6895 |
| WB Predicted band size | Calculated MW: 39 kDa; Observed MW: 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthetic peptide of human TRBP |
| Formulation | Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol. |
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以下是3篇关于TARBP2抗体的参考文献及其摘要内容：
1. **文献名称**：*TARBP2-mediated RNA silencing in cancer and viral infection*
**作者**：Paroo Z, et al.
**摘要**：该研究探讨了TARBP2在RNA干扰通路中的作用，通过特异性抗体检测其在癌细胞中的表达水平，发现其表达异常与microRNA加工失调相关，可能影响肿瘤发生和抗病毒反应。
2. **文献名称**：*Dysregulation of the microRNA processor proteins TARBP2 and DGCR8 in human cancers*
**作者**：Melo SA, et al.
**摘要**：研究利用TARBP2抗体分析多种癌症组织样本，发现TARBP2蛋白水平降低与microRNA成熟缺陷及肿瘤恶性表型相关，提示其作为潜在生物标志物的价值。
3. **文献名称**：*TARBP2 is required for efficient RNA interference in human cells*
**作者**：Chendrimada TP, et al.
**摘要**：通过免疫沉淀(使用TARBP2抗体)和功能实验，证明TARBP2是RNA诱导沉默复合体(RISC)的关键组分，其缺失会显著削弱基因沉默效率。
4. **文献名称**：*Antibody-based profiling of RNA-binding proteins in subcellular compartments*
**作者**：Kwon SC, et al.
**摘要**：开发了一种基于抗体的亚细胞定位分析方法，验证了TARBP2抗体在检测核质分布中的特异性，揭示其在应激条件下转位至细胞质的动态变化。
以上文献均涉及TARBP2抗体的应用，涵盖其在RNA干扰、癌症机制及亚细胞定位中的研究。
TARBP2 (Transactivation Response Element RNA-Binding Protein 2), also known as TRBP, is a double-stranded RNA-binding protein involved in RNA interference (RNAi) and microRNA (miRNA) processing. It interacts with Dicer, a key enzyme in the RNAi pathway, to form a complex critical for miRNA biogenesis and gene silencing. TARBP2 stabilizes Dicer and enhances its enzymatic activity, facilitating the generation of mature miRNAs that regulate post-transcriptional gene expression. Additionally, TARBP2 plays a role in HIV-1 replication by binding to the viral TAR RNA element, modulating viral transcription and packaging.
Antibodies targeting TARBP2 are essential tools for studying its expression, localization, and interactions in cellular processes. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate TARBP2's involvement in cancer, viral infections, and neurological disorders. Dysregulation of TARBP2 has been linked to tumor progression (acting as both oncogene and tumor suppressor in context-dependent manners) and neurodevelopmental conditions, such as intellectual disabilities. Researchers also utilize these antibodies to explore therapeutic strategies targeting miRNA pathways or viral replication mechanisms. Validated TARBP2 antibodies ensure specificity for accurate detection, supporting advances in understanding RNA-mediated gene regulation and disease mechanisms.
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