| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/50-1/200 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 3 keto acyl CoA synthase ELOVL5; Elongation of very long chain fatty acids like 5; ELOVL 5; ELOVL family member 5; ELOVL family member 5 elongation of long chain fatty acids; ELOVL fatty acid elongase 5; ELOVL2; elovl5; Fatty acid elongase 1; hELO1; RP3 483K16.1; RP3-483K16.1; ;ELOVL5 |
| WB Predicted band size | 35 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | A synthesized peptide derived from human ELOVL5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是3-4条关于ELOVL5抗体的参考文献示例(注：以下内容为模拟示例，实际文献需根据具体数据库检索)：
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1. **文献名称**: *"ELOVL5 regulates lipid metabolism and promotes cancer cell invasion via AKT signaling in glioblastoma"*
**作者**: Zhang Y, et al.
**摘要**: 本研究利用ELOVL5特异性抗体，通过Western blot和免疫组化分析，发现ELOVL5在胶质母细胞瘤中高表达，并证明其通过调控脂肪酸合成激活AKT通路，促进肿瘤侵袭。抗体特异性验证显示其可识别ELOVL5蛋白的C末端表位。
2. **文献名称**: *"Role of ELOVL5 in hepatic steatosis: Insights from antibody-based protein localization and knockout models"*
**作者**: Tanaka K, et al.
**摘要**: 研究通过抗ELOVL5抗体进行肝脏组织免疫荧光染色，发现ELOVL5在小鼠肝细胞脂滴周围富集。基因敲除实验表明，ELOVL5缺失导致ω-3/ω-6多不饱和脂肪酸合成减少，加剧高脂饮食诱导的脂肪肝。
3. **文献名称**: *"Development and validation of a novel monoclonal antibody against human ELOVL5 for diagnostic applications"*
**作者**: Müller S, et al.
**摘要**: 本研究报道了一种新型ELOVL5单克隆抗体的开发，通过ELISA和免疫印迹验证其高特异性。该抗体成功应用于结直肠癌患者组织芯片分析，显示ELOVL5表达水平与患者生存率呈负相关。
4. **文献名称**: *"ELOVL5-mediated lipid metabolism in neurodegeneration: Antibody-based profiling in Alzheimer's disease models"*
**作者**: Chen L, et al.
**摘要**: 使用ELOVL5抗体对阿尔茨海默病模型小鼠脑组织进行分析，发现ELOVL5在海马区神经元中表达上调，且与神经炎症相关脂质介质积累相关。抑制ELOVL5可减轻模型中的神经退行性病变。
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如需具体文献，建议通过PubMed或Web of Science以“ELOVL5 antibody”为关键词检索，筛选涉及抗体应用(如WB/IHC/IF)的论文。
The ELOVL5 (Elongation of Very Long Chain Fatty Acids-Like 5) antibody is a crucial tool for studying the ELOVL5 enzyme, which plays a key role in the elongation of polyunsaturated fatty acids (PUFAs), particularly omega-3 and omega-6 fatty acids. These fatty acids are essential for cellular membrane integrity, signaling pathways, and lipid metabolism. ELOVL5 is predominantly expressed in tissues with high lipid turnover, such as the liver, brain, and adipose tissue, and its activity is linked to metabolic regulation and disease pathogenesis, including cancer, neurodegenerative disorders, and metabolic syndrome.
ELOVL5 antibodies are designed to detect and quantify the expression of the ELOVL5 protein in various experimental models. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate tissue-specific expression patterns, subcellular localization (e.g., endoplasmic reticulum), and regulatory mechanisms under different physiological or pathological conditions. Researchers also utilize these antibodies to explore ELOVL5's role in lipid dysregulation, tumor progression (e.g., in liver or prostate cancer), and its potential as a therapeutic target. Validation of antibody specificity, often through knockout controls, is critical due to structural similarities among ELOVL family members. Recent studies highlight ELOVL5's involvement in ferroptosis and lipid peroxidation, expanding its relevance in redox biology and disease mechanisms.
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