| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fet; Fetub; Fetuin beta; Gugu; Pp63;;Fetuin B |
| WB Predicted band size | Calculated MW: 42 kDa ; Observed MW: 55 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | A synthesized peptide derived from human Fetuin B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.05% BSA and 50% glycerol. |
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以下是关于FetuinB抗体的3篇参考文献示例(注：内容为示例性概括，非真实文献)：
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1. **文献名称**: *Fetuin-B regulates mouse ovarian function and fertility via oocyte-granulosa cell communication*
**作者**: Dietzel E, et al.
**摘要**: 研究利用FetuinB抗体检测其在卵母细胞中的表达，发现FetuinB通过调控颗粒细胞信号通路维持卵母细胞成熟，基因敲除小鼠因卵子发育停滞导致不孕。
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2. **文献名称**: *Fetuin-B as a diagnostic biomarker for liver fibrosis: A multicenter study*
**作者**: Yao L, et al.
**摘要**: 通过ELISA和Western blot(使用FetuinB抗体)发现肝纤维化患者血清FetuinB水平显著升高，提示其可能作为非侵入性肝纤维化检测标志物，并与TGF-β通路激活相关。
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3. **文献名称**: *Fetuin-B promotes tumor metastasis via epithelial-mesenchymal transition in ovarian cancer*
**作者**: Wang X, et al.
**摘要**: 免疫组化(使用FetuinB抗体)显示卵巢癌组织中FetuinB高表达与患者生存率低相关，机制研究表明其通过激活EMT通路促进癌细胞侵袭转移。
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4. **文献名称**: *Antibody-based blockade of Fetuin-B attenuates vascular calcification in diabetic mice*
**作者**: Smith J, et al.
**摘要**: 研究开发了中和性FetuinB抗体，证明其可抑制糖尿病模型小鼠的血管钙化进程，为治疗代谢性疾病相关血管病变提供潜在策略。
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(注：以上文献为模拟示例，实际文献需通过PubMed/Google Scholar检索确认。)
**Background of FetuinB Antibody**
FetuinB, a liver-secreted glycoprotein belonging to the cystatin superfamily, shares structural homology with Fetuin-A but exhibits distinct functional roles. Primarily expressed in the liver and reproductive tissues, FetuinB is implicated in regulating protease activity, mineralization processes, and metabolic pathways. Studies highlight its critical role in fertilization by modulating zona pellucida hardening, preventing polyspermy. Dysregulation of FetuinB is associated with metabolic disorders (e.g., insulin resistance, non-alcoholic fatty liver disease), reproductive abnormalities, and certain cancers.
FetuinB antibodies are essential tools for detecting and quantifying FetuinB in research and diagnostics. Polyclonal or monoclonal antibodies target specific epitopes, enabling applications in Western blotting, ELISA, immunohistochemistry, and functional studies to explore FetuinB's mechanisms. Neutralizing antibodies further help dissect its role in protease inhibition or signaling pathways. Recent interest in FetuinB stems from its potential as a biomarker for metabolic syndrome or ovarian dysfunction, as well as therapeutic targeting in conditions like infertility or liver fibrosis. However, its pleiotropic functions and tissue-specific expression necessitate rigorous validation of antibody specificity to avoid cross-reactivity with homologous proteins like Fetuin-A. Ongoing research aims to clarify its dual roles in health and disease, positioning FetuinB antibodies as pivotal reagents in translational and mechanistic studies.
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