| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CLPP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与CLPP抗体相关的文献摘要概览：
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1. **文献名称**: *"CLPP coordinates proteostasis and metabolic control in the mitochondrial matrix"*
**作者**: Gispert S. et al. (2020)
**摘要**: 研究揭示了线粒体蛋白酶CLPP通过调控基质内蛋白稳态和代谢酶活性的平衡维持线粒体功能。作者使用特异性CLPP抗体验证其在细胞内的定位及敲除模型中的蛋白表达缺失，证明CLPP缺失导致呼吸链复合物异常积累及代谢紊乱。
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2. **文献名称**: *"Antibody-based profiling of mitochondrial CLPP expression in human cancers"*
**作者**: Li Y. et al. (2018)
**摘要**: 该研究开发了一种高特异性CLPP单克隆抗体，用于检测多种癌症组织中线粒体CLPP蛋白的表达水平。结果显示CLPP在乳腺癌和卵巢癌中显著上调，提示其可能作为癌症诊断的生物标志物或治疗靶点。
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3. **文献名称**: *"Mitochondrial protease ClpP modulates oxidative stress and apoptosis in cardiomyocytes"*
**作者**: Wang H. et al. (2019)
**摘要**: 通过免疫组化和Western blot(使用CLPP抗体)，研究发现ClpP在心肌细胞氧化应激中通过降解错误折叠蛋白调控线粒体自噬和凋亡通路。CLPP功能缺失加剧心肌缺血再灌注损伤，提示其可作为心脏疾病的干预靶点。
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**备注**：以上文献为示例性质，实际引用时建议通过PubMed或学术数据库(如Web of Science)检索最新论文。若需具体文献DOI或补充信息，可进一步说明研究方向(如疾病模型、抗体开发等)。
CLPP (Caseinolytic Mitochondrial Matrix Peptidase Proteolytic Subunit) is a key component of the mitochondrial ATP-dependent Clp protease complex, which plays a critical role in maintaining protein quality control within the mitochondrial matrix. As a member of the conserved Clp protease family, CLPP functions as a serine protease that degrades misfolded, damaged, or surplus proteins through its proteolytic activity. It works in concert with the regulatory subunit CLPX (ATPase component) to recognize, unfold, and process substrate proteins, ensuring mitochondrial proteostasis and supporting essential processes like oxidative phosphorylation, metabolism, and stress response.
CLPP antibodies are valuable tools for studying mitochondrial proteostasis mechanisms and associated diseases. Mutations in the CLPP gene have been linked to human disorders such as Perrault syndrome (characterized by hearing loss and ovarian dysfunction) and mitochondrial encephalopathies. Researchers utilize CLPP-specific antibodies in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate CLPP expression patterns, subcellular localization, and dysregulation in disease models. These antibodies also aid in exploring CLPP's role in mitochondrial unfolded protein response (UPRmt) pathways and its potential involvement in aging, cancer, or neurodegenerative conditions. Recent studies further highlight CLPP's emerging role in metabolic regulation and apoptosis, expanding its relevance in both basic research and therapeutic development.
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