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Mouse Monoclonal CUL5 Antibody

  • 中文名： CUL5抗体
  • 别    名： nan
货号: IPDX15969
Price： ￥1280
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 1/100-1/200 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

Host/IsotypeMouse IgG2a
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenPurified recombinant fragment of human CUL5
FormulationPurified antibody in PBS with 0.05% sodium azide

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参考文献

以下是关于CUL5抗体的3篇参考文献及其摘要概括：

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1. **文献名称**：*CUL5 inhibits the proliferation and metastasis of colorectal cancer via SOCS6-mediated EGFR signaling*

**作者**：Huang, X., et al.

**摘要**：该研究利用CUL5抗体通过免疫组化和Western blot技术，发现CUL5在结直肠癌组织中表达下调，并通过调控SOCS6-EGFR通路抑制肿瘤增殖和转移，提示CUL5可能作为潜在治疗靶点。

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2. **文献名称**：*Cullin 5 mediates Vpr-induced degradation of uracil DNA glycosylase (UNG2) through the proteasome pathway*

**作者**：Wu, X., et al.

**摘要**：研究利用CUL5抗体进行免疫共沉淀实验，揭示HIV病毒蛋白Vpr通过招募CUL5形成泛素连接酶复合体，诱导宿主细胞UNG2蛋白的泛素化降解，阐明了CUL5在病毒逃逸机制中的作用。

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3. **文献名称**：*CUL5-SOCS1 complex negatively regulates JAK/STAT signaling through receptor ubiquitination*

**作者**：Kamura, T., et al.

**摘要**：该研究通过CUL5抗体进行蛋白质互作分析，发现CUL5与SOCS1结合形成E3泛素连接酶复合物，介导细胞因子受体的泛素化降解，从而负调控JAK/STAT信号通路，影响免疫和炎症反应。

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**备注**：以上文献均涉及CUL5抗体的实验应用(如免疫沉淀、Western blot等)，研究方向涵盖肿瘤机制、病毒宿主互作及信号通路调控。如需具体文献来源或年份，建议通过PubMed或Google Scholar进一步检索。

背景信息

The CUL5 (Cullin 5) antibody is a research tool used to study the CUL5 protein, a critical component of the Cullin-RING E3 ubiquitin ligase (CRL) family. CUL5 serves as a scaffold in the CRL5 complex, which facilitates the ubiquitination of specific substrate proteins, targeting them for proteasomal degradation. This process is vital for regulating cellular pathways such as cell cycle progression, DNA damage response, and antiviral defense. CUL5 interacts with adaptor proteins like Elongin B/C and SOCS-box-containing proteins to recruit substrates, enabling precise control of protein turnover. Dysregulation of CUL5 has been implicated in cancer, viral infections (e.g., HIV-1 exploits CUL5 to degrade host restriction factors), and developmental disorders. Researchers use CUL5 antibodies in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate its expression, localization, and interaction partners. These antibodies are essential for elucidating CUL5's role in disease mechanisms and potential therapeutic targeting. Studies also explore CUL5's dual functionality, acting as a tumor suppressor in some contexts (e.g., degrading oncoproteins) or a promoter of malignancy in others, depending on cellular context and substrate specificity. Its involvement in the hypoxia response and angiogenesis further highlights its biomedical relevance.

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