| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Purified recombinant fragment of human TRIM72 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于TRIM72抗体的3篇参考文献(示例为模拟文献，实际引用需核实具体数据库)：
1. **文献名称**：*TRIM72 modulates skeletal muscle regeneration by regulating membrane repair and myoblast adhesion*
**作者**：Cheng et al.
**摘要**：该研究利用TRIM72抗体检测其在骨骼肌损伤修复中的表达，发现TRIM72通过调控细胞膜修复和成肌细胞黏附促进肌肉再生，抗体染色显示其在损伤部位显著富集。
2. **文献名称**：*Antibody-based targeting of TRIM72 protects against ischemia-reperfusion injury in the heart*
**作者**：Li et al.
**摘要**：研究通过TRIM72抗体阻断实验，证明TRIM72在心肌缺血再灌注损伤中起关键作用，抗体干预可减少细胞死亡并改善心脏功能。
3. **文献名称**：*TRIM72 interacts with dysferlin and regulates vesicle trafficking in muscular dystrophy models*
**作者**：Wang et al.
**摘要**：利用TRIM72抗体共沉淀技术，揭示TRIM72与肌营养不良蛋白dysferlin互作，调控囊泡运输，抗体敲低实验表明其功能缺失加剧肌纤维膜修复障碍。
建议通过PubMed或Web of Science检索关键词“TRIM72 antibody”获取真实文献。
TRIM72. also known as MG53. is a member of the tripartite motif (TRIM) protein family characterized by conserved RING, B-box, and coiled-coil domains. Primarily expressed in skeletal and cardiac muscle, TRIM72 plays a critical role in cell membrane repair by orchestrating vesicle trafficking and exocytosis to reseal damaged membranes. It acts as a scaffold protein, recruiting intracellular vesicles to injury sites through interactions with phospholipids and cytoskeletal components. This membrane repair mechanism is vital for maintaining muscle integrity and protecting against stress-induced damage.
Research highlights TRIM72's involvement in pathological conditions, including muscular dystrophy, myocardial infarction, and diabetes. Its dysregulation is linked to impaired membrane repair, contributing to disease progression. TRIM72 antibodies are essential tools for detecting protein expression, localization, and functional studies. They enable investigations into TRIM72's role in cellular repair mechanisms, its interaction partners, and its potential as a therapeutic target or biomarker. Polyclonal and monoclonal antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to assess TRIM72 levels in disease models or genetic knockout studies.
Current challenges include understanding tissue-specific regulation of TRIM72 and its dual roles in membrane repair and pathological processes like fibrosis or insulin resistance. TRIM72 antibodies also hold promise for developing antibody-based therapies to enhance tissue repair in degenerative diseases.
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