| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CHCHD6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CHCHD6抗体的3篇代表性文献的简要概括(注：以下内容为示例，具体文献需根据实际检索结果调整)：
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1. **文献名称**: "Mitochondrial targeting of CHCHD6 regulates cellular redox homeostasis and apoptosis"
**作者**: Lee, Y., et al.
**摘要**: 该研究利用特异性CHCHD6抗体验证了其在HeLa细胞线粒体中的定位，揭示了CHCHD6通过调节线粒体活性氧(ROS)水平影响细胞凋亡，并与氧化应激通路相关蛋白存在相互作用。
2. **文献名称**: "Development of a high-affinity anti-CHCHD6 monoclonal antibody for neurodegenerative disease diagnostics"
**作者**: Wang, H., et al.
**摘要**: 研究团队开发了一种高灵敏度单克隆CHCHD6抗体，通过免疫印迹和免疫组化验证其特异性，并应用于阿尔茨海默病患者脑组织样本，发现CHCHD6表达水平与tau蛋白病理呈负相关。
3. **文献名称**: "CHCHD6 modulates mitochondrial dynamics and cancer metastasis via antibody-validated protein interactions"
**作者**: Chen, X., et al.
**摘要**: 通过CHCHD6抗体共免疫沉淀技术，研究发现其与线粒体动力蛋白Drp1结合，调控线粒体分裂，进一步在肺癌模型中证实CHCHD6缺失促进癌细胞转移。
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**提示**：实际文献需通过PubMed、Web of Science等平台以关键词“CHCHD6 antibody”或“CHCHD6 immunohistochemistry”检索，并筛选涉及抗体开发、验证或应用的原创研究。部分研究可能发表于《Journal of Cell Biology》《Cell Death & Disease》等期刊。
The CHCHD6 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 6) antibody is a tool used to detect and study the CHCHD6 protein, a member of the CHCHD family implicated in mitochondrial function and cellular stress responses. CHCHD6 localizes primarily to mitochondria and interacts with components of the mitochondrial contact site and cristae organizing system (MICOS), playing roles in maintaining cristae structure, energy metabolism, and apoptosis regulation. Dysregulation of CHCHD6 has been linked to neurodegenerative diseases, cancer, and metabolic disorders due to its involvement in oxidative stress pathways and mitochondrial dynamics.
The CHCHD6 antibody enables researchers to investigate these mechanisms through techniques like Western blotting, immunofluorescence, and immunohistochemistry. It is particularly valuable in studies exploring mitochondrial dysfunction in conditions such as Alzheimer’s disease, Parkinson’s disease, and glioblastoma. Commercial CHCHD6 antibodies are typically validated for specificity across human and model organism samples, though batch variability and cross-reactivity with homologous proteins (e.g., CHCHD3 or CHCHD10) require careful experimental controls. Recent studies also highlight its potential as a biomarker or therapeutic target, driving demand for reliable detection tools. Overall, the CHCHD6 antibody serves as a critical reagent for unraveling mitochondrial biology and disease pathology.
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