| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CAMK2D |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇与CAMK2D抗体相关的模拟参考文献示例(注：以下为模拟内容，建议通过PubMed或Google Scholar获取真实文献)：
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1. **文献名称**: *"CAMK2D as a therapeutic target in cardiac hypertrophy: Antibody-based inhibition studies"*
**作者**: Srinivasan, M. et al.
**摘要**: 研究利用特异性CAMK2D抗体抑制心肌细胞中该激酶的活性，发现抗体阻断可显著减轻小鼠模型中的病理性心脏肥大，提示CAMK2D抗体在心脏疾病治疗中的潜在应用。
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2. **文献名称**: *"Development of a high-affinity monoclonal antibody against CAMK2D for cancer biomarker detection"*
**作者**: Zhang, L. et al.
**摘要**: 报道了一种新型单克隆抗体的开发，该抗体通过ELISA和免疫组化验证可特异性识别CAMK2D蛋白，并在多种肿瘤组织中检测到其高表达，为癌症诊断提供了新工具。
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3. **文献名称**: *"CAMK2D isoform-specific antibody reveals distinct roles in pancreatic β-cell function"*
**作者**: Xu, Y. et al.
**摘要**: 利用亚型特异性CAMK2D抗体研究发现，该激酶在胰岛素分泌调控中具有关键作用，抗体介导的功能抑制实验表明其与Ⅱ型糖尿病发病机制相关。
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**建议**：可通过关键词“CAMK2D antibody application”或“CAMK2D inhibitor antibody”在学术数据库中检索真实文献，重点关注抗体在疾病机制、诊断或治疗中的具体应用。
The CAMK2D antibody targets the delta isoform of calcium/calmodulin-dependent protein kinase II (CaMKIIδ), a serine/threonine kinase central to calcium-mediated signaling pathways. CaMKII is a multimeric enzyme composed of α, β, γ, and δ subunits, with CAMK2D being predominantly expressed in cardiac muscle, smooth muscle, and certain neuronal tissues. It plays a critical role in regulating cellular processes such as gene transcription, apoptosis, and ion channel activity. CAMK2D activation occurs via calcium/calmodulin binding and autophosphorylation, enabling sustained kinase activity even after calcium signals diminish.
CAMK2D dysfunction is linked to cardiovascular diseases, including cardiac hypertrophy, arrhythmias, and heart failure, as well as neurological disorders and cancer. Antibodies against CAMK2D are essential tools for studying its expression, localization, and activation status in tissues or cells. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CAMK2D's role in disease mechanisms or signaling cascades. Specificity validation (e.g., knockout controls) is crucial due to structural similarities among CaMKII isoforms. Research applications also include exploring CAMK2D as a potential therapeutic target, particularly in heart disease and oncology, where its aberrant activity may drive pathological processes.
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