| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 1/100-1/200 | Human,Mouse,Rat |
| IHC | 1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Rat IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human FGA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于FGA(纤维蛋白原α链)抗体的3篇示例性文献摘要，供参考(注：文献为模拟示例，建议通过学术数据库获取真实研究)：
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1. **标题**：*Autoantibodies against fibrinogen alpha chain in antiphospholipid syndrome*
**作者**：Smith A, et al.
**摘要**：研究探讨抗FGA抗体在抗磷脂综合征(APS)患者中的临床意义。通过ELISA检测发现，约30%的APS患者血清中存在抗FGA抗体，且与血栓事件风险增加相关，提示其可能作为APS的生物标志物。
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2. **标题**：*Fibrinogen alpha chain antibodies in systemic lupus erythematosus*
**作者**：Chen L, et al.
**摘要**：分析系统性红斑狼疮(SLE)患者中抗FGA抗体的表达及其与疾病活动度的关联。研究发现，高滴度抗FGA抗体与肾脏损伤(如狼疮肾炎)显著相关，表明其在SLE病理机制中的潜在作用。
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3. **标题**：*Prognostic value of anti-FGA antibodies in thrombotic disorders*
**作者**：Garcia R, et al.
**摘要**：回顾性研究评估抗FGA抗体对不明原因静脉血栓患者的预后价值。结果显示，抗FGA抗体阳性患者的复发风险较阴性组高2倍，提示其可能用于指导抗凝治疗决策。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词：*"fibrinogen alpha chain antibodies" / "anti-FGA autoantibodies"*。
Fibrinogen alpha chain (FGA) antibodies are autoantibodies targeting the alpha subunit of fibrinogen, a critical glycoprotein involved in blood coagulation and wound healing. Fibrinogen, synthesized primarily in the liver, circulates in plasma as a hexamer composed of two sets of three polypeptide chains (Aα, Bβ, and γ). During clot formation, thrombin cleaves fibrinogen, releasing fibrinopeptides and generating fibrin monomers that polymerize into a mesh, stabilizing blood clots.
FGA antibodies are implicated in various pathological conditions. In autoimmune disorders like anti-phospholipid syndrome (APS), these antibodies may disrupt fibrinogen’s normal function, contributing to thrombotic events or bleeding complications. They are also associated with rare fibrinogen deficiencies (e.g., afibrinogenemia or hypofibrinogenemia), where mutations in the *FGA* gene lead to abnormal protein expression, triggering immune responses. Additionally, FGA autoantibodies have been observed in certain cancers, inflammatory diseases, and liver pathologies, possibly due to aberrant fibrinogen processing or exposure of cryptic epitopes.
Clinically, detecting FGA antibodies aids in diagnosing fibrinogen-related disorders and guiding therapeutic strategies, such as immunosuppression or fibrinogen replacement. Research continues to explore their role in disease mechanisms and potential as biomarkers for thrombosis or autoimmune activity.
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