| WB | 咨询技术 | Human, Rat, Mouse |
| IF | 咨询技术 | Human, Rat, Mouse |
| IHC | 咨询技术 | Human, Rat, Mouse |
| ICC | 技术咨询 | Human, Rat, Mouse |
| FCM | 咨询技术 | Human, Rat, Mouse |
| Elisa | 咨询技术 | Human, Rat, Mouse |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat, Mouse |
| Immunogen | Purified recombinant fragment of human ZBTB17 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于ZBTB17抗体的3篇参考文献概览(注：文献为示例性内容，具体引用请核实真实来源)：
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1. **文献名称**：*ZBTB17 modulates MYC transcription in hematopoiesis and leukemia*
**作者**：Smith J, et al.
**摘要**：本研究利用特异性ZBTB17抗体进行ChIP-seq和Western blot分析，发现ZBTB17通过结合MYC启动子调控其转录活性。在急性髓系白血病(AML)患者样本中，ZBTB17蛋白表达缺失与MYC过表达及不良预后相关。
2. **文献名称**：*Development and validation of a monoclonal antibody for ZBTB17 in human solid tumors*
**作者**：Zhang L, et al.
**摘要**：作者开发了一种高特异性抗ZBTB17单克隆抗体，并通过免疫组化(IHC)和流式细胞术验证其在乳腺癌、肺癌等组织中的检测效果。结果显示ZBTB17在肿瘤组织中低表达，且与患者生存率显著相关。
3. **文献名称**：*ZBTB17 suppresses hepatocellular carcinoma progression via p53-dependent pathways*
**作者**：Wang Y, et al.
**摘要**：通过免疫沉淀(IP)和免疫荧光技术结合ZBTB17抗体，研究发现ZBTB17与p53蛋白相互作用，增强其稳定性以抑制肝癌细胞增殖。抗体实验进一步证实ZBTB17在肝癌组织中的表达下调。
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**提示**：实际研究中建议通过PubMed或Google Scholar以“ZBTB17 antibody”、“ZBTB17 function”等关键词检索最新文献，并关注抗体货号(如Santa Cruz的sc-xxxx)对应的原始研究。
The ZBTB17 antibody is a crucial tool for studying the ZBTB17 protein, a member of the zinc finger and BTB/POZ domain-containing (ZBTB) family. ZBTB17. also known as MYC-interacting zinc finger protein 1 (MIZ1) or zinc finger protein 151 (ZNF151), functions as a transcription regulator with dual roles in gene activation and repression. Structurally, it contains an N-terminal BTB/POZ domain for protein-protein interactions and C-terminal zinc finger motifs for DNA binding. ZBTB17 is implicated in diverse cellular processes, including cell cycle control, apoptosis, and differentiation, often through interactions with oncoproteins like MYC. While MYC-ZBTB17 complexes typically repress target genes, ZBTB17 alone may activate growth-inhibitory pathways, highlighting its context-dependent role in cancer biology.
Antibodies targeting ZBTB17 enable detection and quantification of its expression in tissues or cultured cells via techniques like Western blot, immunohistochemistry, and immunofluorescence. They are essential for investigating ZBTB17's nuclear localization, protein interactions, and dysregulation in diseases such as malignancies, immune disorders, and developmental syndromes. Commercial ZBTB17 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences, with validation in knockout controls to ensure specificity. Researchers utilize these tools to explore ZBTB17's tumor-suppressive or oncogenic functions, epigenetic regulation mechanisms, and therapeutic potential in precision medicine.
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