| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | S3-12; KIAA1881 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human PLIN4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于PLIN4抗体的参考文献，简要总结如下：
1. **文献名称**: *"Perilipin 4 (PLIN4) Coats Lipid Droplets in Skeletal Muscle and Regulates Fatty Acid Metabolism"*
**作者**: Smith A, et al.
**摘要**: 本研究通过特异性PLIN4抗体进行免疫荧光和Western blot分析，发现PLIN4在小鼠骨骼肌脂滴表面富集，调控脂肪酸氧化。抗体验证显示其对PLIN4的高特异性，适用于肌肉组织样本。
2. **文献名称**: *"PLIN4 Expression in Human Adipose Tissue: Association with Obesity and Insulin Resistance"*
**作者**: Chen L, et al.
**摘要**: 利用商业化PLIN4抗体(货号ABC123)对肥胖患者脂肪组织进行免疫组化分析，发现PLIN4表达与胰岛素抵抗呈负相关。研究强调了抗体在区分PLIN4与其他Perilipin家族蛋白中的可靠性。
3. **文献名称**: *"Validation of a Novel Polyclonal Antibody for PLIN4 Detection in Cancer Cell Lines"*
**作者**: Gupta R, et al.
**摘要**: 开发并验证了一种兔源多克隆PLIN4抗体，通过siRNA敲低和质谱法确认其特异性。该抗体适用于流式细胞术和免疫沉淀，揭示了PLIN4在肿瘤细胞脂代谢中的潜在作用。
(注：以上文献为示例，实际引用时需核对真实数据库如PubMed或Web of Science获取准确信息。)
**Background of PLIN4 Antibody**
Perilipin 4 (PLIN4), also known as S3-12. is a member of the perilipin family of lipid droplet (LD)-associated proteins that regulate lipid storage and metabolism. It is primarily expressed in adipose tissue and plays a role in stabilizing LDs, particularly during lipolysis and lipid mobilization. PLIN4 is distinct from other perilipins due to its unique structural features, including repetitive sequences that may facilitate interactions with LD surfaces.
Antibodies targeting PLIN4 are critical tools for studying its expression, localization, and function in metabolic processes. Research using PLIN4 antibodies has revealed its involvement in conditions such as obesity, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). For instance, PLIN4 expression is upregulated in adipose tissue during obesity, suggesting a compensatory role in managing lipid overload.
PLIN4 antibodies are also employed to investigate its tissue-specific roles, including its contribution to hepatic lipid metabolism and potential cross-talk with other perilipin family members (e.g., PLIN1. PLIN2). Additionally, studies have explored PLIN4's relevance in cancer, where altered lipid metabolism in tumor cells may depend on LD-associated proteins.
Overall, PLIN4 antibodies serve as essential reagents for elucidating the molecular mechanisms of lipid storage diseases and metabolic disorders, offering insights for therapeutic targeting.
×
