Rabbit Polyclonal KIAA0556 Antibody

The KIAA0556 gene, also known as **FAM110B**, encodes a protein with incompletely characterized functions, though it is implicated in microtubule organization and cilia-related processes. Antibodies targeting KIAA0556/FAM110B are primarily utilized in basic research to explore its role in cellular dynamics, particularly in cell cycle regulation, cytoskeletal remodeling, and ciliogenesis. Studies suggest its potential involvement in neurodevelopmental pathways and cancer biology, as aberrant expression has been observed in gliomas and other malignancies. KIAA0556 antibodies are typically produced in hosts like rabbits or mice, employing recombinant protein fragments or synthetic peptides as immunogens. These tools enable detection via techniques such as Western blotting, immunofluorescence, and immunohistochemistry, aiding in subcellular localization studies—often showing cytoplasmic or centrosomal distribution. Commercial availability varies, with some antibodies validated for specificity using knockout controls or siRNA-mediated silencing. Despite limited clinical applications to date, KIAA0556 antibodies remain critical for elucidating its interaction networks, including associations with microtubule-associated proteins and signaling molecules like Aurora kinases. Ongoing research aims to clarify its contributions to ciliopathies, mitotic errors, and tissue-specific pathologies, highlighting its emerging relevance in cell biology and disease mechanisms.