Rabbit Polyclonal FBXO45 Antibody

The FBXO45 antibody is a research tool designed to detect FBXO45. a member of the F-box protein family that functions as a substrate-recognition component within the SCF (SKP1-CUL1-F-box) E3 ubiquitin ligase complex. FBXO45 plays critical roles in ubiquitin-mediated proteasomal degradation, regulating processes such as neuronal development, synaptic plasticity, and cancer progression. It is particularly noted for its interaction with specific substrates, including the E3 ligase MYCBP2 (PHR1) and the pro-apoptotic protein IP3R1. which it modulates to influence cellular survival and differentiation. In neuroscience, FBXO45 is essential for maintaining axonal integrity and synaptic function, with studies linking its dysfunction to neurodevelopmental disorders. In oncology, FBXO45 exhibits dual roles, acting as a tumor suppressor by degrading oncoproteins or as a promoter in certain cancers depending on cellular context. Antibodies targeting FBXO45 are utilized in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to study its expression, localization, and protein interactions. Validation of these antibodies often involves knockout cell lines or siRNA-mediated silencing to confirm specificity. Current research focuses on elucidating FBXO45’s substrate spectrum, regulatory mechanisms, and therapeutic potential in diseases like glioblastoma and neuroblastoma. Challenges remain in fully mapping its binding partners and context-dependent roles, underscoring the importance of reliable FBXO45 antibodies in advancing molecular and clinical research.